脊柱结核患者TNF-α基因多态性研究

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摘要目的探讨肿瘤坏死因子-α(tumor necrosis factor-α，TNF-α)基因启动子区-238A/G、-308A/G位点的基因多态性与脊柱结核的关系。方法随机抽取新疆医科大学第六附属医院2015年1月至12月收治的脊柱结核患者58例及对照组50例作为研究对象，采取病例-对照方法对两组TNF-α-238 A/G、-308A/G位点的基因多态性进行比较，并使用统计学方法进行分析。结果病例组与对照组TNF-α-238位点GG、GA基因型频率比较差异有统计学意义，P＜0.05；两组-238位点G、A等位基因型频率比较差异无统计学意义，P＞0.05；两组TNF-α-308位点GG、GA基因型频率比较差异无统计学意义，P＞0.05；两组308位点G、A等位基因频率比较差异均有统计学意义，P＜0.05。结论 TNF-α基因参与了脊柱结核的发生发展过程，且基因多态性和和结核易感性有关，其中-308A等位基因和-238位点GA基因可能参与了脊柱结核的发生。

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	张玉坤
	周纲
	黄卫民

关键词 ：脊柱结核, TNF-α, 基因, 等位基因

Abstract：Objective To investigate the association of TNF-α gene polymorphisms at position -238A/G and -308A/G with spine tuberculosis.Methods We randomly selected 58 cases of spinal tuberculosis patients and 50 normal people as control group from January to December in 2015 of Sixth Affiliated Hospital in Xinjiang Medical University.Gene polymorphisms with the -308A/G and-238A/G of TNF alpha were studied.Results There was significant difference in genotype frequencies of region at position -238GG and GA in TNF-α gene between spinal tuberculosis patients and control group，P＜0.05.There was no significant difference in allele frequencies of region at position-238G and A between two groups，P＞0.05.There was no significant difference in genotype frequencies of region at position-308GG and GA in TNF-α gene between two groups，P＞0.05.There was significant difference in allele frequencies of region at position -308G and A between two groups，P＜0.05.Conclusion TNF-α genes involved the development process of spinal tuberculosis，and gene polymorphism was susceptibility with TB，-308 A allele and -238 GA gene may be involved with the occurrence of spinal tuberculosis.

Key words： spinal tuberculosis TNF-α gene allele

基金资助:新疆医科大学创新基金(XJC2013222)

通讯作者: 黄卫民

作者简介: 张玉坤(1979－ )，男，副主任医师，新疆医科大学第六附属医院脊柱二科，830002。

引用本文:

张玉坤，周纲，黄卫民. 脊柱结核患者TNF-α基因多态性研究[J]. 实用骨科杂志, 2017, 23(1): 25-27.
Zhang Yukun，Zhou Gang，Huang Weiming. Polymorphismsin Analysis of TNF-α Gene in the Patients with Spine Tuberculosis. sygkzz, 2017, 23(1): 25-27.

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http://www.sygkzz.com/CN/ 或 http://www.sygkzz.com/CN/Y2017/V23/I1/25

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