Abstract：Objective To establish two models of osteolysis induced by wear particles，and to compare the indexes of inflammation，osteolysis and osteoclast count and provide a basis for the selection of animal models of osteolysis.Methods The air pouch mouse model and murine calvarial osteolysis model were established. The morphology was observed by HE staining，the osteolysis was observed by scanning electron microscope，and the osteoclast count was performed by TRAP staining.Results The bone resorption area (385.30±5.11) nm2 of the air pouch mouse model was significantly higher than that of the murine calvarial osteolysis model (288.60±4.89) nm2 (P＜0.05)，and the number of osteoclast cells (16.75±0.53) in the air pouch mouse model was significantly higher than that of the murine calvarial osteolysis model (9.55±0.48) (P＜0.05).Conclusion All of the two animal models were successfully constructed，and the air pouch mouse model is better than that of the murine calvarial osteolysis model in the level of inflammation，osteolysis and osteoclast count，so the air pouch mouse model is better in the simulation of osteolysis induced by wear particles.
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