新型人工颈椎间盘山羊模型的建立及其研究

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摘要目的观察新型国产人工颈椎间盘植入山羊体内后的效果，为其进一步的改进和临床应用提供实验基础。方法 12只雄性山羊，均行C_3～4新型国产人工颈椎间盘置换术。所有山羊于术前及术后不同时间点均行颈椎正侧位X线检查，测量C_3～4节段椎间高度(disc height，DH)，椎间角(intervertebral angle，IVA)和脊柱功能单位(functional spinal unit，FSU)Cobb角，并进行统计学分析。结果所有实验山羊均成活，无伤口感染，未出现瘫痪。术后第2天，有一只山羊出现声音嘶哑，但1周后逐渐恢复正常。术前及术后不同时间点的C_3～4节段椎间高度、IVA和FSU Cobb角的对比分析显示，差异均无统计学意义。结论新型国产人工颈椎间盘系统操作简便，实验动物术后并发症少，且较好的维持了目标节段椎间高度和颈椎生理曲度。

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关键词 ：新型颈椎间盘假体, 颈椎间盘置换, 动物模型, 动物实验, 颈椎曲度

Abstract：Objective To observe the effect of novel domestic-made artificial cervical disc in vivo with goat model，in order to provide an experimental basis for further improvement and clinical application.Methods 12 male experimental goats underwent C_3～4 novel domestic-made artificial cervical disc replacement.All the goats were examined preoperatively and postoperatively on anteroposterior and lateral radiographs.The disc height (DH)，intervertebral angle (IVA) and functional spinal unit (FSU) lordosis angle were measured and analyzed statistically.Results All experimental goats survived after operation，without incision infection and paralysis.Hoarseness occurred in one goat the second day after operation，and disappeared one week later.Statistical comparison in DH，IVA and FSU lordosis angle at C_3～4 segment showed no significant difference among different time points.Conclusion Novel domestic-made artificial cervical disc system is easy to operate，has less complications，and can maintain the postoperative disc height and cervical spinal curvature well.

Key words： new cervical disc prosthesis cervical disc replacement animal model animal experiment cervical curvature

基金资助:四川省科技支撑计划(2014SZ0236)

作者简介: 娄纪刚(1988－ )，男，博士研究生在读，四川大学华西医院骨科，610041。

引用本文:

娄纪刚 1，刘浩 1，武文杰 2，李会波 1，王贝宇 1，戎鑫 1. 新型人工颈椎间盘山羊模型的建立及其研究[J]. 实用骨科杂志, 2017, 23(5): 426-429.
Lou Jigang1，Liu Hao1，Wu Wenjie2，et al. Establishment of Novel Artificial Cervical Disc Goat Model and Related Study. sygkzz, 2017, 23(5): 426-429.

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http://www.sygkzz.com/CN/ 或 http://www.sygkzz.com/CN/Y2017/V23/I5/426

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