可降解锌合金骨植入材料的研究进展

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (548 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要由于创伤、感染和骨肿瘤切除以及先天性疾病等因素导致的骨缺损患者逐年增多，部分骨质丧失造成的骨不连、骨萎缩甚至畸形等并发症，是临床常见且较难治疗的疾病之一。目前对大段骨缺损的治疗主要是应用来源有限的自体骨或异体骨，以及应用不锈钢、钛合金等骨替代材料进行移植，以填充骨缺损并促进其修复和重建，虽然金属填充材料的力学性能较好，但在人体内不能降解，长时间滞留体内所产生的金属离子对周围组织造成一定的损害，因为其弹性模量远大于人骨骼的弹性模量，所以会产生应力遮挡效应等问题。因此，寻找一种可降解骨植入材料逐渐成为近年的研究热点。Zn是一种可降解金属，其降解速率比Mg慢、比Fe快，其降解趋势更为平缓。由于其良好的生物安全性、特定的力学性能和适宜的降解速率，Zn合金有望成为一种理想的骨植入材料。本文就Zn合金的生物学性能、影响因素和作为骨植入材料的应用以及存在的问题与对策做一简要综述。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	曹向昱
	车浩东
	李亚庚
	田华

通讯作者: 田华

作者简介: 曹向昱(1991－ )，男，研究生在读，北京大学第三医院骨科，caoxiangyu2018@163.com

引用本文:

曹向昱，车浩东，李亚庚，田华. 可降解锌合金骨植入材料的研究进展[J]. 实用骨科杂志, 2024, 30(1): 54-.

链接本文:

http://www.sygkzz.com/CN/ 或 http://www.sygkzz.com/CN/Y2024/V30/I1/54

［1］ Zhuang Y，Liu Q，Jia G，et al.A biomimetic zinc alloy scaffold coated with brushite for enhanced cranial bone egeneration［J］.ACS Biomater Sci Eng，2021，7(3)：893-903.
［2］ Liu JY，Wang JG，Yu YH，et al.Advances in biodegradable vascular stent materials［J］.Mater Sci Forum，2020(987)：93-98.
［3］ Katari G，Goldman J，Aghion E.The prospects of zinc as a structural material for biodegradable implants-A review paper［J］.Metals，2017，7(10)：402.
［4］ Kafri A，Ovadia S，Goldman J，et al.The suitability of Zn-1.3% Fe alloy as a biodegradable implant material［J］.Metals，2018，8(3)：153.
［5］ Bai W，Shin J，Fu R，et al.Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity［J］.Nat Biomed Eng，2019，3(8)：644-654.
［6］ Qu X，Yang H，Yu Z，et al.Serum zinc levels and multiple health outcomes：Implications for zinc-based biomaterials［J］.Bioact Mater，2020，5(2)：410-422.
［7］ Mostaed E，Sikora-Jasinska M，Mostaed A，et al.Novel Zn-based alloys for biodegradable stent applications：Design，development and in vitro degradation［J］.J Mech Behav Biomed Mater，2016(60)：581-602.
［8］ Zhu S，Wu C，Li G，et al.Creep properties of biodegradable Zn-0.1Li alloy at human body temperature：Implications for its durability as stents［J］.Mater Res Lett，2019，7(9)：347-353.
［9］ Yang H，Jia B，Zhang Z，et al.Alloying design of biodegradable zinc as promising bone implants for load-bearing applications［J］.Nat Commun，2020，11(1)：401.
［10］ Trne KB，Khan FA，rnberg A，et al.Zn-Mg and Zn-Ag degradation mechanism under biologically relevant conditions［J］.Surf Innov，2018，6(1-2)：81-92.
［11］ Zhao S，Seitz JM，Eifler R，et al.Zn-Li alloy after extrusion anddrawing：Structural，mechanical characterization，and biodegradation in abdominal aorta of rat［J］.Mater Sci Eng C Mater Biol Appl，2017(76)：301-312.
［12］ Shen C，Liu Xi-wei，Fan Bo，et al.Mechanical properties，in vitro degradation behavior，hemocompa-tibility and cytotoxicity evaluation of Zn-1.2Mg alloy for biodegradable implants［J］.ACS Appl Bio Mater，2016，6(89)：86410-86419.
［13］ Li Qinglin，Wei Min，Yang Jing，et al.Effect of Ca Addition on the microstructure，mechanical properties and corrosion rate of degradable Zn-1mg alloys［J］.J Alloys Compd，2021(887)：161255.
［14］ Tang Z，Niu J，Huang H，et al.Potential biodegradable Zn-Cu binary alloys developed for cardiovascular implant applications［J］.J Mech Behav Biomed Mater，2017(72)：182-191.
［15］ Jia B，Yang H，Zhang Z，et al.Biodegradable Zn-Sr alloy for bone regeneration in rat femoral condyle defect model：In vitro and in vivo studies［J］.Bioact Mater，2020，6(6)：1588-1604.
［16］ Liu C，Li Y，Ge Q，et al.Mechanical characteristics and in vitro degradation of biodegradable Zn-Al alloy［J］.Mater Lett，2021(300)：130181.
［17］ Mao M，Zhu S，Zhang L，et al.An Extracellular Matrix-like Surface for Zn Alloy to Enhance Bone Regeneration［J］.ACS Appl Mater Interfaces，2022，14(38)：43955-43964.
［18］ Deren Z，Dong C，Xue F，et al.Bioactive coating with antibacterial and anticorrosive propert IES deposited on ZA6-1 alloy bone implant［J］.Trans Nonferrous Met Soc China，2023，33(5)：1507-1521.
［19］ Su YC，Wamg K，Gao Jl，et al.Enhanced cytocompatibility and antibacterial property of zinc phosphate coating on biodegradable zinc materials［J］.Acta Biomaterialia，2019(98)：174-185.
［20］ Mo XS，Qian JY，Chen YQ，et al.Corrosion and degradation decelerating alendronate embedded zinc phosphate hybrid coating on biodegradable Zn biomaterials［J］.Corros Sci，2021(184)：109398.
［21］ Sun J，Zhang X，Shi ZZ，et al.Adjusting comprehensive properties of biodegradable Zn-Mn alloy through solution heat-treatment［J］.Mater Today Commun，2020(23)：101150.
［22］ Wtroba M，Bednarczyk W，Kawalko J，et al.A novel high-strength Zn-3Ag-0.5Mg alloy processed by hot extrusion，cold rolling，or high-pressure torsion［J］.Metallurgical and Materials Transactions A，2020，51(7)：3335-3348.
［23］ Liu H，Huang H，Zhang Y，et al.Evolution of Mg-Zn second phases during ECAP at different processing temperatures and its impact on mechanical properties of Zn-1.6Mg (wt%)alloys［J］.J Alloys Compd，2019(811)：151987.
［24］ Venezuela J，Dargusch MS.The influence of alloying and fabrication techniques on the mechanical properties，biodegradability and biocompatibility of zinc：A comprehensive review［J］.Acta Biomaterialia，2019(87)：1-40.
［25］ Chen YQ，Zhang WT，Maitz MF，et al.Comparative corrosion behavior of Zn with Fe and Mg in the course of immersion degradation in phosphate buffered saline［J］.Corros Sci，2016(111)：541-555.
［26］ Zhao S，Mcnamara CT，Bowen PK，et al.Structural characteristics and in vitro biodegradation of a novel Zn-Li alloy prepared by induction melting and hot rolling［J］.Metallurgical and Materials Transacttons A，2017(48)：1204-1215.
［27］ Li P，Dai J，Schweizer E，et al.Response of human periosteal cells to degradation products of zinc and its alloy［J］.Mater Sci Eng C Mater Biol Appl，2020(108)：110208.
［28］ Mostaed E，Sikora-Jasinska M，Drelich JW，et al.Zinc-based alloys for degradable vascular stent applications［J］.Acta Biomaterialia，2018(71)：1-23.
［29］ Vojtěch D，Kubásek J，Serák J，et al.Mechanical and corrosion properties of newly developed biodegradable Zn-based alloys for bone fixation［J］.Acta Biomaterialia，2011，7(9)：3515-3522.
［30］ Capek J，Kubasek J，Pinc J，et al.Microstructural，mechanical，in vitro corrosion and biological characterization of an extruded Zn-0.8Mg-0.2Sr (wt%) as an absorbable material［J］.Mater Sci Eng C Mater Biol Appl，2021(122)：111924.
［31］王顺，冯微，廖燚，等.锌-2银-0.4镁多孔合金支架的体外生物相容性、成骨性及抗菌性能评价［J］.实用骨科杂志，2022，28(9)：801-806.
［32］ Guo P，Zhu X，Yang L，et al.Ultrafine-and uniform-grained biodegradable Zn-0.5Mn alloy：Grain refinement mechanism，corrosion behavior，and biocompatibility in vivo［J］.Mater Sci Eng C Mater Biol Appl，2021(118)：111391.
［33］ Xiao C，Wang L，Ren Y，et al.Indirectly extruded biodegradable Zn-0.05 wt% Mg alloy with improved strength and ductility：In vitro and in vivo studies［J］.J Mater Sci Technol，2018，34(9)：1618-1627.
［34］ Wang J，Xia H，Fan X，et al.Biodegradable Zn-2Ag-0.04Mg alloy for bone regeneration in vivo［J］.Mol Biotechnol，2022，64(8)：928-935.
［35］ Jia B，Zhang Z，Zhuang Y，et al.High-strength biodegradable zinc alloy implants with antibacterial and osteogenic properties for the treatment of MRSA-induced rat osteomyelitis［J］.Biomaterials，2022(287)：121663.
［36］ Sun J，Zhang X，Shi ZZ，et al.Development of a high-strength Zn-Mn-Mg alloy for ligament reconstruction fixation［J］.Acta Biomater，2021(119)：485-498.
［37］ Shao X，Wang X，Xu F，et al.In vivo biocompatibility and degradability of a Zn-Mg-Fe alloy osteosynthesis system［J］.Bioact Mater，2021(7)：154-166.
［38］ Jia B，Yang H，Han Y，et al.in vitro and in vivo studies of Zn-Mnbiodegradable metals designed for orthopaedic applications［J］.Acta Biomaterialia，2020(108)：358-372.
［39］ Amin N，Clark CCT，Taghizadeh M，et al.Zinc supplements and bone health：The role of the RANKL-RANK axis as a therapeutic target［J］.J Trace Elem Med Biol，2020(57)：126417.
［40］秦骥，杨勇.国际首例可降解锌合金接骨板手术在西安施行［N］.陕西日报，2020-10-25(5).