原发性膝骨关节炎合并高血压的临床研究

摘要
图/表
参考文献
相关文章 (15)

全文: PDF (474 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要目的探讨原发性膝骨关节炎(osteoarthritis，OA)合并高血压的患病情况和临床特点。方法回顾性分析膝OA行人工关节置换术后患者104例，按有无合并高血压分为高血压病膝OA组61例和单纯膝OA组43例，比较两组患者的临床资料。结果合并高血压病的膝骨关节炎组膝关节功能评分显著低于不伴有高血压的患者(P＝0.001，t＝－6.345)，女性患者更明显(P＝0.001，t＝－7.558)；伴高血压病的膝骨关节炎患者肥胖率明显大于不伴高血压者(P＝0.001，χ²＝14.785)；伴高血压的女性膝骨关节炎患者骨质疏松比例明显高于没有高血压者(P＝0.016，Z＝5.823)。结论高血压可能通过力学因素和代谢性炎症因素促进原发性膝OA的发生和发展，其中对女性膝关节功能的影响更加明显。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章

关键词 ：骨关节炎, 高血压, 肥胖, 骨质疏松

Abstract：Objective To explore relationship between hypertension and joint function of OA.Methods Clinical data of 104 OA patients with or without hypertension were analyzed retrospectively.Results the HSS score was significantly lower in OA with hypertension than in simple OA and especially the female cases.Hypertension in OA was significantly positively related to obesity.Conclusion Hypertension may significantly relate to both occurrence and progression of OA，especially to female’s OA.Hypertension prevention may be useful in reducing future OA risk.

Key words： knee osteoarthritis arterial hypertension obesity osteoporosis

基金资助:山西省科技攻关项目(20150313012-6)

通讯作者: 杨朝晖

作者简介: 黄志(1981－)，男，主治医师，山西医科大学第二医院骨科，030001。

引用本文:

黄志 1，2，刘瀚霖 2，魏垒 1，李鹏翠 1，郭卫宾 1，刘笑君 1，杨朝晖 1*. 原发性膝骨关节炎合并高血压的临床研究[J]. 实用骨科杂志, 2017, 23(4): 319-322.
Huang Zhi 1，2，Liu Hanlin 2，Wei Lei 1，et al. Relationship between Hypertension and Osteoarthritis of Knee. sygkzz, 2017, 23(4): 319-322.

链接本文:

http://www.sygkzz.com/CN/ 或 http://www.sygkzz.com/CN/Y2017/V23/I4/319

［1］Lawrence JS.Hypertension in relation to musculoskeletal disorders［J］.Ann Rheum Dis，1975，34(5)：451-456.
［2］中华医学会风湿病学分会.骨关节炎诊治指南(草案)［J］.中华风湿病学杂志，2003，7(11)：702-704.
［3］Dieppe PA，Lohmander LS.Pathogenesis and management of pain in osteoarthritis［J］.Lancet，2005，365(9463)：965-973.
［4］Fernandes GS，Valdes AM.Cardiovascular disease and osteoarthritis：common pathways and patient outcomes［J］.Eur J Clin Invest，2015，45(4)：405-414.
［5］孟娟.膝骨关节炎合并代谢综合征的临床研究［J］.中华风湿病学杂志，2014，189(11)：758-761.
［6］Hart DJ，Doyle DV，Spector TD.Association between metabolic factors and knee osteoarthritis in women：the Chingford Study［J］.J Rheumatol，1995，22(6)：1118-1123.
［7］Yoshimura N，Muraki S，Oka H，et al.Accumulation of metabolic risk factors such as overweight，hypertension，dyslipidaemia，and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis：a 3-year follow-up of the ROAD study［J］.Osteoarthritis Cartilage，2012，209(11)：1217-1226.
［8］Findlay DM.Vascular pathology and osteoarthritis［J］.Rheum (Oxford)，2007，46(12)：1763-1768.
［9］Wen CY，Chen Y，Tang HL，et al.Bone loss at subchondral plate in knee osteoarthritis patients with hypertension and type 2 diabetes mellitus［J］.Osteoarthritis Cartilage，2013，21(11)：1716-1723.
［10］Sokolove J，Lepus CM.Role of inflammation in the pathogenesis of osteoarthritis：latest findings and interpretations［J］.Ther Adv Musculoskelet Dis，2013，5(2)：77-94.
［11］Felson DT.Osteoarthritis as a disease of mechanics［J］.Osteoarthritis Cartilage，2013，21(1)：10-15.
［12］Ding C，Cicuttini F，Scott F，et al.Natural history of knee cartilage defects and factors affecting change［J］.Arch Inter Med，2006，166(6)：651-658.
［13］Clockaerts S，Bastiaansen-Jenniskens YM，Runhaar J，et al.The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue：a narrative review［J］.Osteoarthritis Cartilage，2010，18(7)：876-882.
［14］Ushiyama T，Chano T，Inoue K，et al.Cytokine production in the infrapatellar fat pad：another source of cytokines in knee synovial fluids［J］.Ann Rheum Dis，2003，62(2)：108-112.
［15］Rojas-Rodriguez J，Escobar-Linares LE，Garcia-Carrasco M，et al.The relationship between the metabolic syndrome and energy-utilization deficit in the pathogenesis of obesity-induced osteoarthritis［J］.Med Hypotheses，2007，69(4)：860-868.
［16］Nuzzo A，Rossi R，Modena MG.Hypertension alone or related to the metabolic syndrome in postmenopausal women［J］.Expert Rev Cardiovasc Ther，2010，8(11)：1541-1548.
［17］Cappuccio FP，Meilahn E，Zmuda JM，et al.High blood pressure and bone-mineral loss in elderly white women：a prospective study.Study of Osteoporotic Fractures Research Group［J］.Lancet，1999，354(9183)：971-975.
［18］Titze J，Rittweger J，Dietsch P，et al.Hypertension，sodium retention，calcium excretion and osteopenia in Dahl rats［J］.J Hypertens，2004，22(4)：803-810.
［19］Sowers JR，White WB，Pitt B，et al.The Effects of cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory therapy on 24-hour blood pressure in patients with hypertension，osteoarthritis，and type 2 diabetes mellitus［J］.Arch Inter Med，2005，165(2)：161-168.
［20］Ilic K，Obradovic N，Vujasinovic-Stupar N.The relationship among hypertension，antihypertensive medications，and osteoporosis：a narrative review［J］.Calcif Tissue Int，2013，92(3)：217-227.