Relationship between Hypertension and Osteoarthritis of Knee
1.Department of Orthopedic,2nd Hospital of Shanxi Medical University
2.Department of Orthopeadics,Hanyang Hospital,Wuhan University of Science and Technology
Abstract:Objective To explore relationship between hypertension and joint function of OA.Methods Clinical data of 104 OA patients with or without hypertension were analyzed retrospectively.Results the HSS score was significantly lower in OA with hypertension than in simple OA and especially the female cases.Hypertension in OA was significantly positively related to obesity.Conclusion Hypertension may significantly relate to both occurrence and progression of OA,especially to female’s OA.Hypertension prevention may be useful in reducing future OA risk.
[1]Lawrence JS.Hypertension in relation to musculoskeletal disorders[J].Ann Rheum Dis,1975,34(5):451-456.
[2]中华医学会风湿病学分会.骨关节炎诊治指南(草案)[J].中华风湿病学杂志,2003,7(11):702-704.
[3]Dieppe PA,Lohmander LS.Pathogenesis and management of pain in osteoarthritis[J].Lancet,2005,365(9463):965-973.
[4]Fernandes GS,Valdes AM.Cardiovascular disease and osteoarthritis:common pathways and patient outcomes[J].Eur J Clin Invest,2015,45(4):405-414.
[5]孟娟.膝骨关节炎合并代谢综合征的临床研究[J].中华风湿病学杂志,2014,189(11):758-761.
[6]Hart DJ,Doyle DV,Spector TD.Association between metabolic factors and knee osteoarthritis in women:the Chingford Study[J].J Rheumatol,1995,22(6):1118-1123.
[7]Yoshimura N,Muraki S,Oka H,et al.Accumulation of metabolic risk factors such as overweight,hypertension,dyslipidaemia,and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis:a 3-year follow-up of the ROAD study[J].Osteoarthritis Cartilage,2012,209(11):1217-1226.
[8]Findlay DM.Vascular pathology and osteoarthritis[J].Rheum (Oxford),2007,46(12):1763-1768.
[9]Wen CY,Chen Y,Tang HL,et al.Bone loss at subchondral plate in knee osteoarthritis patients with hypertension and type 2 diabetes mellitus[J].Osteoarthritis Cartilage,2013,21(11):1716-1723.
[10]Sokolove J,Lepus CM.Role of inflammation in the pathogenesis of osteoarthritis:latest findings and interpretations[J].Ther Adv Musculoskelet Dis,2013,5(2):77-94.
[11]Felson DT.Osteoarthritis as a disease of mechanics[J].Osteoarthritis Cartilage,2013,21(1):10-15.
[12]Ding C,Cicuttini F,Scott F,et al.Natural history of knee cartilage defects and factors affecting change[J].Arch Inter Med,2006,166(6):651-658.
[13]Clockaerts S,Bastiaansen-Jenniskens YM,Runhaar J,et al.The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue:a narrative review[J].Osteoarthritis Cartilage,2010,18(7):876-882.
[14]Ushiyama T,Chano T,Inoue K,et al.Cytokine production in the infrapatellar fat pad:another source of cytokines in knee synovial fluids[J].Ann Rheum Dis,2003,62(2):108-112.
[15]Rojas-Rodriguez J,Escobar-Linares LE,Garcia-Carrasco M,et al.The relationship between the metabolic syndrome and energy-utilization deficit in the pathogenesis of obesity-induced osteoarthritis[J].Med Hypotheses,2007,69(4):860-868.
[16]Nuzzo A,Rossi R,Modena MG.Hypertension alone or related to the metabolic syndrome in postmenopausal women[J].Expert Rev Cardiovasc Ther,2010,8(11):1541-1548.
[17]Cappuccio FP,Meilahn E,Zmuda JM,et al.High blood pressure and bone-mineral loss in elderly white women:a prospective study.Study of Osteoporotic Fractures Research Group[J].Lancet,1999,354(9183):971-975.
[18]Titze J,Rittweger J,Dietsch P,et al.Hypertension,sodium retention,calcium excretion and osteopenia in Dahl rats[J].J Hypertens,2004,22(4):803-810.
[19]Sowers JR,White WB,Pitt B,et al.The Effects of cyclooxygenase-2 inhibitors and nonsteroidal anti-inflammatory therapy on 24-hour blood pressure in patients with hypertension,osteoarthritis,and type 2 diabetes mellitus[J].Arch Inter Med,2005,165(2):161-168.
[20]Ilic K,Obradovic N,Vujasinovic-Stupar N.The relationship among hypertension,antihypertensive medications,and osteoporosis:a narrative review[J].Calcif Tissue Int,2013,92(3):217-227.