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Abstract Objective To produce flexible sensors with coaxial printing technology，achieve real-time monitoring of limb circumference and provide continuous monitoring for patients with acute myofascial compartment syndrome and lower extremity deep vein thrombosis in highrisk groups or in the early course of the disease.Methods High-purity gallium-indium alloy and polydimethylsiloxane were used to make cables，and STC89C52 micro-controller as the main control chip was used to design the output and alarm devices.The relationship between the tensile degree of the cable and the change in resistance was verified，and the relationship among the tensile degree，the resistance value and the change in the output value were also explored.We verifed the credibility of the result in the balloon and in the healthy people.Results The cable stretch degree-resistance change curve was continuous.The resistance increases with the increase of stretch degree，and the resistance measurement value was statistically significant when different thicknesses of silica gel strips were stretched by 200%.After connecting the output device，the output value increased with increasing resistance.Under the 10Ω alarm threshold，the stretch degree of the same cable was similar，and statistically significant among different cables.Limb expansion was similuated with balloon expansion and healthy human limb movement.Repeated experiments showed same trend of monitor reading changes with circumference changes.Conclusion The flexible sensor made by applying coaxial printing technology can quickly and accurately reflect the changes in the circumference of the subject’s limb，which has good application prospects and provides ideas for the early diagnosis and monitoring of related diseases.
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Corresponding Authors:
Chen Deqi
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［1］Ahluwalia A，Tiwari K，Somashaker N.Acute compartment syndrome in the limb［J］.Br J Hosp Med (Lond)，2020，81(5)：1-6.
［2］Guo J，Yin Y，Jin L，et al.Acute compartment syndrome：Cause，diagnosis，and new viewpoint［J］.Medicine (Baltimore)，2019，98(27)：e16260.
［3］McMillan TE，Gardner WT.Diagnosing acute compartment syndromewhere have we got to?［J］.Int Orthop，2019，43(11)：2429-2435.
［4］Long B，Koyfman A，Gottlieb M.Evaluation and management of acute compartment syndrome in the emergency department［J］.J Emerg Med，2019，56(4)：386-397.
［5］Florou M，Lambropoulos V，Mouravas V，et al.Crush syndrome in a case of severe infant physical abuse：A case report［J］.Pan Afr Med J，2021，39(1)：172-177.
［6］Chen JS，Tejwani NC.Compartment syndrome of the foot［J］.Orthop Clin North Am，2022，53(1)：83-93.
［7］Schneiderman BA，O’Toole RV.Compartment syndrome in highenergy tibial plateau fractures［J］.Orthop Clin North Am，2022，53(1)：43-50.
［8］Sepehri A，Howard LC，Neufeld ME，et al.Compartment syndrome after hip and knee arthroplasty［J］.Orthop Clin North Am，2022，53(1)：25-32.
［9］Zang YP，Zhang FJ，Di CA，et al.Advances of flexible pressure sensors toward artificial intelligence and health care applications［J］.Materials Horizons，2015，2(2)：140-56.
［10］Hammock ML，Chortos A，Tee BC，et al.25th anniversary article：The evolution of electronic skin (e-skin)：A brief history，design considerations，and recent progress［J］.Adv Mater，2013，25(42)：5997-6038.
［11］Cheng S，Rydberg A，Hjort K，et al.Liquid metal stretchable unbalanced loop antenna［J］.Applied Physics Letters，2009，94(14)：3.
［12］Rogers JA，Someya T，Huang YG.Materials and mechanics for stretchable electronics［J］.Science，2010，327(5973)：1603-1607.
［13］Gao W，Emaminejad S，Nyein HYY，et al.Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis［J］.Nature，2016，529(7587)：509-514.
［14］Zhou LY，Gao Q，Zhan JF，et al.Three-dimensional printed wearable sensors with liquid metals for detecting the pose of snakelike soft robots［J］.ACS Appl Mater Interfaces，2018，10(27)：23208-20217.
［15］Lee H，Choi TK，Lee YB，et al.A graphene-based electrochemical device with thermoresponsive microneedles for diabetes monitoring and therapy［J］.Nat Nanotechnol，2016，11(6)：566-572.
［16］Zhao Z，Soni S.Smart eutectic gallium-indium：From properties to applications［J］.Adv Mater，2023，35(1)：e2203391.
［17］Yan HL，Chen YQ，Deng YQ，et al.Coaxial printing method for directly writing stretchable cable as strain sensor［J］.Applied Physics Letters，2016，109(8)：083502.
［18］Kyrle PA，Eichinger S.Deep vein thrombosis［J］.Lancet，2005，366(9480)：119-120.
［19］Marques MA，Panico MDB，Porto CLL，et al.Venous thromboembolism prophylaxis on flights［J］.J Vasc Bras，2018，17(3)：215-219.
［20］Hattab Y，Kung S，Fasanya A，et al.Deep venous thrombosis of the upper and lower extremity［J］.Crit Care Nurs Q，2017，40(3)：230-236.
［21］Bauersachs RM.Clinical presentation of deep vein thrombosis and pulmonary embolism［J］.Best Pract Res Clin Haematol，2012，25(3)：243-251.
［22］Goldhaber SZ，Bounameaux H.Pulmonary embolism and deep vein thrombosis［J］.Lancet，2012，379(9828)：1835-1846.
［23］Browse NL，Thomas ML.Source of non-lethal pulmonary emboli［J］.Lancet，1974，1(7851)：258-259.
［24］Di Nisio M，van Es N，Buller HR.Deep vein thrombosis and pulmonary embolism［J］.Lancet，2016，388(10063)：3060-3073.
［25］Olaf M，Cooney R.Deep venous thrombosis［J］.Emerg Med Clin North Am，2017，35(4)：743-770.
［26］Miranda-Klein J，Howell CM，Davis-Cheshire M.Recognizing and managing upper extremity compartment syndrome［J］.JAAPA，2020，33(5)：15-20.
［27］Cepková J，Ungermann L，Ehler E.Acute compartment syndrome［J］.Acta Medica (Hradec Kralove)，2020，63(3)：124-127.
［28］Harvey EJ，Sanders DW，Shuler MS，et al.What’s new in acute compartment syndrome?［J］.J Orthop Trauma，2012，26(12)：699-702. |
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