D-二聚体联合其他指标检测对脊柱退行性变术后下肢深静脉血栓形成的预测价值

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Abstract Objective To explore the predictive value of D-dimer(D-D) combined with other blood indicators in the formation of deep venous thrombosis(DVT) after spinal degenerative surgery.Methods The clinical data of 583 patients with spinal degenerative surgery received from October 2017 to December 2020 were collected continuously.The patients were divided into two groups according to whether DVT occurred after surgery.There were 60 cases in DVT group，including 28 males and 32 females，with an average age of(65±10)years.There were 523 cases in non-DVT group，including 269 males and 254 females，with an average of(63±12)years.The general clinical data of the two groups were recorded.The levels of five items of coagulation，D-D，fibrin/fibrinogen degradation products(FDP)，C-reactive protein(CRP)，procalcitonin(PCT) and interleukin-6(IL-6) were detected 3 days after surgery.The indicators with statistical differences between the two groups were fitted by logistic regression.The diagnostic efficacy was analyzed by receiver operating characteristic(ROC) curve，and area under curve(AUC) was calculated to estimate the predictive diagnostic value of DVT after spinal degenerative surgery.Results (1)The levels of D-D，FDP and CRP in DVT group were significantly higher than those in non DVT group 3 days after operation(P＜0.05).(2)ROC curve analysis showed that the AUC of D-D，FDP and CRP in predicting the diagnosis of DVT were 0.881(95%CI：0.829~0.933)，0.864(95%CI：0.809~0.919) and 0.815(95%CI：0.759~0.870)，respectively.The AUC of D-D，FDP and CRP in predicting the diagnosis of DVT was 0.912(95%CI：0.861~0.963)，the sensitivity was 76.67%，and the specificity was 90.00%，which were higher than that of the three alone.Conclusion The combined detection of D-D，FDP and CRP can improve the early diagnosis efficiency of the three independent detection for DVT，and has certain judgment value for the prediction diagnosis of DVT formation after spinal degeneration surgery.

Key words： spinal degenerative surgery deep venous thrombosis D-dimer combined detection

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	Aoran·Maheshati
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Aoran·Maheshati,Hali·Habulihan,Yang Yi, et al. Predictive Value of D-Dimer Combined with Other Indicators in Lower Extremity Deep Venous Thrombosis After Spinal Degenerative Surgery[J]. sygkzz, 2021, 27(9): 774-778.

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http://www.sygkzz.com/EN/ OR http://www.sygkzz.com/EN/Y2021/V27/I9/774

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