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Abstract Objective To study the clinical efficacy of a U-shaped rod combined with isthmus bone graftting and single-segment fixation in the treatment of simple lumbar spondylolysis.To analyze the postoperative isthmus fusion and long-term effect.Methods Thirty-seven simple lumbar spondylolysis patients treated with a U-shaped rod combined with isthmic bone grafting and single-segment fixation in University of Chinese Academy of Sciences-Shenzhen Hospital from January 2017 to December 2019 were analyzed retrospectively，including 26 males and 11 females.The age ranged from 17 to 42 years with an average of (26.54±6.32)years.The duration of surgery，intraoperative blood loss and postoperative drainage volume were recorded.The preoperative visual analogue scale(VAS) and Oswestry disability index(ODI) were compared to postoperatively.The fusion of isthmus was observed.Results The patients were followed for 24~60 months postoperatively，with an average of (37.46±9.71)years.The VAS of patients with postoperative low back pain was lower than preoperatively，and the difference was statistically significant (P＜0.05).The ODI after operation was significantly improved compared with that before operation，and the difference was statistically significant (P＜0.05).The bony fusion rate was 82.43%，and the duration of fusion was (8.82±3.63)months.At the final follow-up，none of the patients had secondary lumbar spondylolisthesis or adjacent segmental disc degeneration，there were no complications such as rupture or loosening of internal fixation.Conclusion In the treatment of simple lumbar spondylolysis，a U-shaped rod combined with isthmic bone grafting and single-segment fixation is characterized by a short and simple operation with a small incision，safety，little bleeding and few complications. The surgery relieves lumbago，lumbar function is recovered，the isthmic bony fusion rate is high，and the internal fixation is firm.Therefore，the surgery has definite therapeutic effect.
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