[1]Varady NH,Grodzinsky AJ.Osteoarthritis year in review 2015:mechanics[J].Osteoarthritis Cartilage,2016,24(1):27-35.
[2]Kim H,Kang D,Cho Y,et al.Epigenetic Regulation of Chondrocyte Catabolism and Anabolism in Osteoarthritis[J].Mol Cells,2015,38(8):677-684.
[3]Mobasheri A,Matta C,Zákány R,et al.Chondrosenescence:definition,hallmarks and potential role in the pathogenesis of osteoarthritis[J].Maturitas,2015,80(3):237-244.
[4]Santoro A,Conde J,Scotece M.Choosing the right chondrocyte cell line:Focus on nitric oxide[J].J Orthop Res,2015,33(12):1784-1788.
[5]Wu W,Gao X,Xu X,et al.Saponin-rich fraction from Clematis chinensisOsbeck roots protects rabbit chondrocytes against nitric oxideinduced apoptosis via preventing mitochondria impairment and caspase-3 activation[J].Cytotechnology,2013,65(2):287-295.
[6]Chen Q,Mei X,Han G,et al.Xanthan gum protects rabbit articular chondrocytes against sodium nitroprusside-induced apoptosis in vitro[J].Carbohydr Polym,2015(131):363-369.
[7]Zhou Y,Liu SQ,Yu L,et al.Berberine prevents nitric oxide-induced rat chondrocyte apoptosis and cartilage degeneration in a rat osteoarthritis model via AMPK and p38 MAPK signaling[J].Apoptosis,2015,20(9):1187-1199.
[8]Alvarez-Garcia O,Rogers NH,Smith RG,et al.Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1[J].Arthritis Rheumatol,2014,66(7):1779-1788.
[9]Zheng X,Xia C,Chen Z,et al.Requirement of the phosphatidylinositol 3-kinase/Akt signaling pathway for the effect of nicotine on interleukin-1beta-induced chondrocyte apoptosis in a rat model of osteoarthritis[J].Biochem Biophys Res Commun,2012,423(3):606-612.
[10]Kimura H,Yukitake H,Suzuki H,et al.The Chondroprotective Agent ITZ-1 Inhibits Interleukin-1β–Induced Matrix Metalloproteinase–13 Production and Suppresses Nitric Oxide–Induced Chondrocyte Death[J].J PharmacolSci,2009,110(2):201-211.
[11]Ju XD,Deng M,Ao YF,et al.Protective effect of sinomenine on cartilage degradation and chondrocytes apoptosis[J].Yakugaku Zasshi,2010,130(8):1053-1060.
[12]Cheleschi S,Cantarini L,Pascarelli NA,et al.Possible chondroprotective effect of canakinumab:an in vitro study on human osteoarthritic chondrocytes[J].Cytokine,2015,71(2):165-172.
[13]Guo H,Luo Q,Zhang J,et al.Comparing different physical factors on serum TNF-α levels,chondrocyte apoptosis,caspase-3 and caspase-8 expression in osteoarthritis of the knee in rabbits[J].Joint Bone Spine,2011,78(6):604-610.
[14]Guo FJ,Xiong Z,Lu X,et al.ATF6 upregulates XBP1S and inhibits ER stress-mediated apoptosis in osteoarthritis cartilage[J].Cell Signal,2014,26(2):332-342.
[15]Lee SW,Rho JH,Lee SY,et al.Leptin protects rat articular chondrocytes from cytotoxicity induced by TNF-a in the presence of cyclohexamide[J].Osteoarthritis Cartilage,2015,23(12):2269-2278.
[16]Wei L,Sun XJ,Wang Z,et al.CD95-induced osteoarthritic chondrocyte apoptosis and necrosis:dependency on p38 mitogen-activated protein kinase[J].Arthritis Res Ther,2006,8(2):R37.
[17]Ryu JH,Shin Y,Huh YH,et al.Hypoxia-inducible factor-2α regulates Fas-mediated chondrocyte apoptosis during osteoarthritic cartilage destruction[J].Cell Death Differ,2012,19(3):440-450.
[18]Tu Y,Xue H,Francis W,et al.Lactoferrin inhibits dexamethasone-induced chondrocyte impairment from osteoarthritic cartilage through up-regulation of extracellular signalregulated kinase 1/2 and suppression of FASL,FAS,and Caspase-3[J].Biochem Biophys Res Commun,2013,441(1):249-255.
[19]Duesterdieck-Zellmer KF,Driscoll N,Ott JF.Concentration-dependent effects of tiludronate on equine articular cartilage explants incubated with and without interleukin-1β[J].Am J Vet Res,2012,73(10):1530-1539.
[20]Miwa M,Saura R,Hirata S,et al.Induction of apoptosis in bovine articular chondrocyte by prostaglandin E2 through cAMP-dependent pathway[J].Osteoarthritis Cartilage,2000,8(1):17-24.
[21]Na JY,Kim S,Song K,et al.Anti-apoptotic Activity of GinsenosideRb 1 in Hydrogen Peroxide-treated Chondrocytes:Stabilization of Mitochondria and the Inhibition of Caspase-3[J].J Ginseng Res,2012,36(3):242-247.
[22]Lee SW,Lee HJ,Chung WT,et al.TRAIL Induces Apoptosis of Chondrocytes and Influences the Pathogenesis of Experimentally Induced Rat Osteoarthritis[J].Arthritis Rheum,2004,50(2):534-542.
[23]Derfus BA,Kurian JB,Butler JJ,et al.The high prevalence of pathologic calcium crystals in pre-operative knees[J].J Rheumatol,2002,29(3):570-574.
[24]Ea HK,Monceau V,Camors E,et al.Annexin 5 overexpression increased articular chondrocyte apoptosis induced by basic calcium phosphate crystals[J].Ann Rheum Dis,2008,67(11):1617-1625.
[25]Xu B,Yang H,Sun M,et al.2,3',4,4',5-Pentachlorobiphenyl Induces Inflammatory Responses in the Thyroid Through JNK and Aryl Hydrocarbon Receptor-Mediated Pathway[J].ToxicolSci,2016,149(2):300-311.
[26]Abella V,Santoro A,Scotece M,et al.Non-dioxin-like polychlorinated biphenyls (PCB 101,PCB 153 and PCB 180) induce chondrocyte cell death through multiple pathways[J].Toxicol Lett,2015,234(1):13-19.
[27]Lee HG,Yang JH.PCB126 induces apoptosis of chondrocytes via ROS-dependent pathways[J].Osteoarthritis Cartilage,2012,20(10):1179-1185.
[28]Shane Anderson A,Loeser RF.Why is osteoarthritis an age-related disease?[J].Best Pract Res Clin Rheumatol,2010,24(1):1526.
[29]Yang Q,Guo S,Wang S,et al.Advanced glycation end products-induced chondrocyte apoptosis through mitochondrial dysfunction in cultured rabbit chondrocyte[J].Fundam Clin Pharmacol,2015,29(1):54-61.
[30]Kumagai K,Imai S,Toyoda F,et al.17β-Oestradiol inhibits doxorubicin-induced apoptosis via block of the volume-sensitive Cl- current in rabbit articular chondrocytes[J].Br J Pharmacol,2012,166(2):702-720.
[31]Lin P,Weng X,Liu F,et al.BushenZhuangjin decoction inhibits TM-induced chondrocyte apoptosis mediated by endoplasmic reticulum stress[J].Int J Mol Med,2015,36(6):1519-1528.
[32]Wang L,Gai P,Xu R,et al.Shikonin protects chondrocytes from interleukin-1beta-induced apoptosis by regulating PI3K/Akt signaling pathway[J].Int J Clin Exp Pathol,2015,8(1):298-308.
[33]Huang Y,Wu D,Fan W.Protection of ginsenoside Rg1 on chondrocyte from IL-1β-induced mitochondria-activated apoptosis through PI3K/Aktsignaling[J].Mol Cell Biochem,2014,392(1-2):249-257.
[34]Sakata S,Hayashi S,Fujishiro T,et al.Oxidative stress-induced apoptosis and matrix loss of chondrocytes is inhibited by eicosapentaenoic acid[J].J Orthop Res,2015,33(3):359-365.
[35]Sylvester J,Liacini A,Li WQ,et al.Interleukin-17 signal transduction pathways implicated in inducing matrix metalloproteinase-3,-13 and aggrecanase-1 genes in articular chondrocytes[J].Cell Signal,2004,16(4):469-476.
[36]Tóbon-Velasco JC,Cuevas E,TorresRamos MA.Receptor for AGEs (RAGE) as mediator of NF-kB pathway activation in neuroinflammation and oxidative stress[J].CNS Neurol Disord Drug Targets,2014,13(9):1615-1626.
[37]Qin J,Shang L,Ping AS,et al.TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1b-induced rat osteoarthritis chondrocytes in vitro[J].Arthritis Res Ther,2012,14(6):R242.
[38]Villarino AV1,Kanno Y1,Ferdinand JR1,et al.Mechanisms of Jak/STAT signaling in immunity and disease[J].J Immunol,2015,194(1):21-27.
[39]Greene MA,Loeser RF.Function of the chondrocyte PI-3 kinase-Akt signaling pathway is stimulus dependent[J].Osteoarthritis Cartilage,2015,23(6):949-956.
[40]Lim H,Park H,Kim HP.Effects of flavonoids on matrix metalloproteinase-13 expression of interleukin-1β-treated articular chondrocytes and their cellular mechanisms:inhibition of c-Fos/AP-1 and JAK/STAT signaling pathways[J].J Pharmacol Sci,2011,116(2):221-231.