Objective To evaluate difference of the curative effect between arthroscopic mini-incision therapeutics Herbert nails and open reduction with internal fixation (ORIF) with plate for shoulder dislocation combined large tuberosity fracture of the proximal humerus,and to explore the potential mechanism,so as to provide reliable and effective evidence-based medicine for clinical research.Methods A total of 36 patients with shoulder dislocation combined large tuberosity fracture of the proximal humerus who were treated in our hospital from January 2014 to June 2015 were included in our study and were divided into two groups with arthroscopic mini-incision therapeutics Herbert nails and ORIF with plate.We compared the operation time,inoperative blood loss,hospitalization time and fracture healing time between the two groups,as well as the UCLA score and shoulder joint effect after treatment for 3 months.Results The average operation time,inoperative blood loss and hospitalization time of the Herbert nails under arthroscopy group was significantly better than those of the ORIF with plate group (P<0.05).Fracture healing time of two groups:The facture healing time of the arthroscopic mini-incision therapeutics Herbert nails under arthroscopy group(9.36±0.64) weeks was shorter than the ORIF with plate group (9.36±0.64) weeks vs (10.22±0.96) weeks;t=-4.481,P<0.001).UCLA score after treatment for 3 months of the two groups:The UCLA score for pain and muscle strength of the arthroscopic mini-incision therapeutics Herbert nails group was higher than ORIF with plate group (P<0.05).There was no significant difference of UCLA score for daily life and satisfaction between the two groups (P>0.05).There was a significant difference of total UCLA score between the two groups (P<0.05);Curative effect of shoulder after treatment of the two groups:The excellent/good rate of the arthroscopic mini-incision therapeutics Herbert nails group was higher than the ORIF with plate group (77.78% vs 66.11%;χ2=2.429,P=0.048).Conclusion The arthroscopic mini-incision therapeutics Herbert nails operation is an ideal treatment method for shoulder dislocation combined large tuberosity fracture of the proximal humerus which has advantages of a clear diagnosis,safety-operation,good curative effect,and high dependability,and is worthy to promote in clinical.