Abstract:Objective To Investigate the relationship between osteoporosis and adjacentlevel ossification after nterior cervical decompression and fusion.Methods The clinical data of 105 patients with cervical intervertebral disc herniation who underwent anterior cervical discectomy and fusion(ACDF) between June 2009 and August 2013 were retrospectively analyzed .Bone mineral density (BMD)before and after ACDFs 、the incidence of adjacent-level ossification after ACDFs and the degree of adjacent-level ossification after ACDFs were analysed.Results Adjacent-level ossification after ACDFs related to Low BMD and osteoporosis.Osteoporosis and the severity of adjacent-level ossification after ACDF were positively correlated.The change of Osteoporosis and the severity of adjacent-level ossification after ACDF were negatively correlated.Conclusion It may be helpful to reduce the incidence and the severity of adjacent-level ossification after ACDF by using anti-osteoporosis drug.
[1]Cloward RB.The anterior approach for removal of ruputured cervical disk[J].J Neurosurg,2007,6(5):496-511.
[2]Smith GW,Robinson RA.The treatment of certain cervicalspine disorders by anterior removal of the intervertebral disc and interbody fusion[J].J Bone Joint Surg(Am),1958,40(3):607-624.
[3]Garringer SM,Sasso RC.Safety of anterior cervical discectomy and fusion performed as outpatient surgery[J].J Spinal Disord Tech,2010,23(7):439-443.
[4]Zeng JH,Zhong ZM,Chen JT,et al.Early dysphagia complicating anterior cervical spine surgery:incidence and risk factors[J].Arch Orthop Trauma Surg,2012,133(8):1067-1071.
[5]3Rd RL,Skolasky RL,Albert TJ,et al.Dysphagia after anterior cervical decompression and fusion:prevalence and risk factors from a longitudinal cohort study[J].Spine,2005,30(22):2564-2569.
[6]俞杭平,唐天驷,王以进,等.颈前路单椎间减压植骨融合与加用钛板内固定的比较研究[J].中华骨科杂志,2003,23(9):549-553.
[7]陈昆,蔡惠民,陈荣滋,等.Zero-P与钛板+椎间融合器内固定治疗颈椎间盘突出近中期疗效对比[J].实用骨科杂志,2016,22(3):193-197.
[8]蒋欣,谭明生.颈椎前路融合术后发生症状性邻近节段退变的临床研究[J].中医正骨,2007,20(12):808-811.
[9]陈戈,段洪,卞鸿燕,等.脊柱退行性疾病的骨质疏松影响分析[J].中国骨质疏松杂志,2014,20(7):766-770.
[10]张智海,刘忠厚,李娜,等.中国人骨质疏松症诊断标准专家共识(2014版)[J].中国骨质疏松杂志,2014,20(9):1007-1010.
[11]Yang H,Chen D,Wang X,et al.Zero-profile integrated plate and spacer device reduces rate of adjacent-level ossification development and dysphagia compared to ACDF with plating and cgae system[J].Arch Orthop Trauma Surg,2015,135(6):781-787.
[12]Park JB,Cho YS,Riew KD,et al.Development of adjacent-level ossification in patients with an anterior cervical plate[J].J Bone Joint Surg(Am),2005,87(3):558-563.
[13]车彪,邵增务,杨述华,等.颈前路减压融合钛板内固定治疗脊髓型颈椎病[J].实用骨科杂志,2009,15(1):18-20.
[14]武刚,申勇.颈椎病前路手术的并发症[J].中国矫形外科杂志,2009,17(13):1315-1318.
[15]Joaquim AF,Murar J,Savage JW,et al.Dysphagia after anterior cervical spine surgery:a systematic review of potential preventative measures[J].Spine J,2014,14(9):2246-2260.
[16]祁敏,梁磊,王新伟,等.颈前路多节段融合术后吞咽困难的原因分析[J].中华骨科杂志,2013,33(5):467-472.
[17]马志兵,冯虎,袁峰,等.颈椎前路减压固定融合术后钢板固定位置对相邻节段退变的影响[J].中国脊柱脊髓杂志,2010,20(3):201-204.
[18]Yang JY,Song HS,Lee M,et al.Adjacent level ossification development after anterior cervical fusion without plate fixation[J].Spine,2009,34(1):30-33.
[19]Zhang L,Wang J,Tao Y,et al.Outcome evaluation of zero-profile implant compared with an anterior plate and cage used in anterior cervical discectomy and fusion:a two-year follow-up study[J].Turkish Neurosurgery,2014,26(3):416-422.
[20]Eck JC,Humphreys SC,Lim TH,et al.Biomechanical study on the effect of cervical spine fusion on adjacent 2 level intradiscal pressure and segmentalmotion[J].Spine,2002,27 (22):2431-2434.
[21]Baba H,Furusawa N,Imura S,et al.Late radiographic findings after and terior cervical fusion for spondylotic myeloradiculopathy[J].Spine,1993,18(15):2167-2173.
[22]蒋欣,谭明生.颈椎前路融合术后发生症状性邻近节段退变的临床研究[J].中医正骨,2007,20(12):808-811.
[23]赵燕玲,潘子昂,王石麟.中国原发性骨质疏松症流行病学[J].中国骨质疏松杂志,1998,4(1):l-4.
[24]Yang BP,Ondra SL,Chen LA,et al.Clinical and radiographic outcomes of thoracic and lumbar pedicle subtraction osteotomy for fixed sagittal imbalance[J].J Neurosurg Spine,2006,5(1):9-17.
[25]Mummaneni PV,Burkus JK,Haid RW,et al.Clinical and radiographic analysis of cervical disc arthroplasty compared with allograft fusion:a randomized controlled clinical trial[J].J Neurosurg Spine,2007,6(3):198-209.
[26]Sugawara T,Itoh Y,Hirano Y,et al.Long term outcome and adjacent disc degeneration after anterior cervical discectomy and fusion with titanium cyl indrical cages[J].Acta Neurochir (Wien),2009,151(4):303-309.
[27]崔莹,冯正平.抗骨质疏松药物的研究进展[J].中国骨质疏松杂志,2015,21(3):367-371.
[28]刘飞,王亮,李大伟,等.腰椎退行性疾病伴骨质疏松患者行腰椎融合术后应用唑来膦酸的临床疗效观察[J].中国骨质疏松杂志,2015,21(4):434-438.