长链非编码RNA在脊髓损伤中的研究进展

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摘要脊髓损伤(spinal cord injury，SCI)是一种高发生率、高致残率、高死亡率的中枢神经系统创伤性疾病，其病理过程主要包括原发性和继发性两个损伤阶段。在骨折、压迫等导致的原发性损伤后，继发的炎症反应、组织缺氧、神经元坏死凋亡、局部抑制性微环境等一系列病理生理的变化进一步加重了脊髓损伤，进而导致严重的感觉和运动功能障碍。因此，探究SCI后病理生理改变的发生机制对于脊髓损伤的研究和修复具有极其重要的意义。长链非编码RNAs(long non-coding RNAs，lncRNAs)被定义为长度大于200个核苷酸的非编码RNA转录本。目前已有研究表明，lncRNAs可以通过调节染色质、转录及转录后修饰来调节下游基因的表达，这被认为是许多疾病研究的新方向。目前关于lncRNAs在SCI中作用的研究相对较少，且缺乏较为全面的综述。本文对近年来lncRNAs在SCI中的分子功能相关的研究进行了综述，并进一步探讨了lncRNAs作为SCI预后相关生物标志物及治疗靶点等方面的潜在作用，旨在较为全面的了解lncRNAs在SCI中所发挥的作用。

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	周恒星 1
	亢毅 1
	李雪莹 2
	史仲举 1
	卢璐 1
	张驰 1
	刘路 1
	娄永富 1
	蔡志威 1
	冯世庆 1*

基金资助:国家自然科学基金青年基金(81501899)
国家自然科学基金重点项目(81330042)
国家自然科学基金重点国际(地区)合作研究项目(81620108018)

通讯作者: 冯世庆

作者简介: 周恒星(1984－ )，男，主治医师，天津医科大学总医院，300052。

引用本文:

周恒星 1，亢毅 1，李雪莹 2，史仲举 1，卢璐 1，张驰 1，刘路 1，娄永富 1，蔡志威 1，冯世庆 1*. 长链非编码RNA在脊髓损伤中的研究进展[J]. 实用骨科杂志, 2018, 24(9): 820-859.

链接本文:

http://www.sygkzz.com/CN/ 或 http://www.sygkzz.com/CN/Y2018/V24/I9/820

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