PAF含量及血小板参数变化在膝骨关节炎中的诊断价值研究

Abstract
Figure/Table
References (0)
Related Citation (14)

Download: PDF (1413 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To observe the changes of PAF content and platelet parameters of patients with knee osteoarthritis.To investigate theireffects in the treatment of knee osteoarthritis and theirusages as diagnostic and prognostic indicators in clinical application.Methods 20 cases of healthy people and 96 cases of patients with knee replacement surgery patients were included in this study.The platelet parameters was tested by five classifications of blood cells，the PAF content in serum and articular fluid was tested by enzyme-linked immunosorbent assay.And statistical analysis was performed in all results.Results Compared with the normal group，the MPV，PCT and PDW of knee arthritis group increased slightly.The deference was statistically significant between the two groups(P＜0.05).The MPV，PCT and PDW of knee arthritis group decreasedto normal levels after treatment，The deference was not statistically significant between normal group and posttreatment group (P＞0.05)，The deference was statistically significant between normal group and knee arthritis group(P＜0.05).The deference of PLT as not statistically significant in all groups.The r value of each group was calculate by platelet parameters related analysis.The r value of MPV in each group was 0.001、0.64、0.001，respectively(P＝0.00);the r value of PLT in each group was 0.001，0.52，0.001，respectively (P＝0.00);the r value of PDW in each group was 0.001，0.58，0.001，respectively (P＝0.00).The above parameters were statistically significant between knee arthritis group and post-treatment group (P＜0.05). The r value of PLT was 0.001，0.001，0.001，respectively (P＝0.00)，The difference of it was not statistically significant in all groups.The PAF content inserum of knee arthritis group was 6.7 times as normal group's and the platelet parameters in articular fluid of knee arthritis groupand7 times as the normal group's.The deference was statistically significant between the two groups(P＜0.05).The PAF content inserum of post-treatment group was 5.6 times as normal group's and the platelet parameters in articular fluid of post-treatment group was 6.1 times as the normal group's.The deference was not statistically significant between the two groups(P＞0.05).The r value of PAF in serum and articular fluid was calculate by analysis in all groups.Only the knee arthritis group' result was relatedto PAF.The r value was rserum 0.78，rarticulart-fluid 0.82(P＝0.00)，respectively.The differnecewas statistically significant (P＞0.05).Conclusion PAF，MPV，PCT and PDW are related to the knee osteoarthritis and can be used as one of the laboratory diagnostic indicators in clinical diagnosis and prognosis.

Key words： platelet-activating factor platelet parameters knee osteoarthritis

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Suo Cangping
	Ye Yongjie

Cite this article:

Suo Cangping,Ye Yongjie. The Diagnostic Value of PAF Content and Changes of Platelet Parameters in Osteoarthritis of the Knee[J]. sygkzz, 2018, 24(1): 39-43.

URL:

http://www.sygkzz.com/EN/ OR http://www.sygkzz.com/EN/Y2018/V24/I1/39

［1］Vlachogianni IC，Fragopoulou E，Stamatakis GM，et al.Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions.［J］.Prostaglandins Other Lipid Mediat，2015，121(Pt B)：176-183.
［2］Weber E，Theisen D，Wilmes P，et al.A new quantitative measure for radiologic osteoarthritis of the lateral knee compartment distinguishes patients with longstanding lateral meniscectomy from non-pathological knees［J］.Knee Surq Sports Traumatol Arthrosc，2016，24(5)：1569-1574.
［3］王勇.中药配合玻璃酸钠治疗膝关节骨关节炎疗效观察［J］.实用中医药杂志，2009，25(1)：20-21.
［4］王清洋，王林.臭氧对兔骨性关节炎的关节软骨及关节液蛋白多糖含量的影响［J］.中国疼痛医学杂志，2012，18(7)：400-403.
［5］赏后来，郭亭.骨关节炎实验室诊断指标的意义及研究进展［J］.医学研究生学报，2012，25(2)：204-207.
［6］邹妮，鲁佑瑜.血小板活化因子与心血管疾病［J］.中国医学文摘：内科学，2004，25(3)：399-402.
［7］李书芳，刘翠青.新生儿急性肺损伤血中内皮细胞因子变化及意义［J］.中华现代儿科学杂志，2005，2(9)：810-812.
［8］Kurose R，Ichinohe S，Tajima G，et al.Characterization of human synovial fluid cells of 26 patients with osteoarthritis knee for cartilage repair therapy［J］.Int J Rheum Dis，2010，13(1)：68-74.
［9］牛记军，乔君元，唐笑先，等.非离子型造影剂过敏反应者血清类糜蛋白酶前列腺素 D2 及血小板活化因子的变化观察［J］.中国药物与临床，2015，15(6)：746-748.
［10］牟立东，樊瑞军.血小板平均体积及分布宽度临床价值的探讨［J］.宁夏医学院学报，1997，19(3)：24-25.
［11］韩琳琳.血细胞分析仪检测网织血小板诊断血液相关疾病的意义［J］.中国继续医学教育，2016，8(3)：53-55.
［12］陈晖.血液病患者血小板MPV、PCT、PDW的检测意义［J］.中华全科医学，2006，4(4)：479-479.
［13］Hu D，Zhang T，Zhang Z，et al.Toxicity to the hematopoietic and lymphoid organs of piglets treated with a therapeutic dose of florfenicol［J］.Vet Immunol Immunopathol，2014，162(3)：122-131.