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Abstract Objective To investigate the correlation between serum bone alkaline phosphatase (BALP) level and bone volume in elderly patients with osteoporosis (OP).
Methods 73 elderly patients with OP from the People’s Hospital of Xinjiang Uygur Autonomous Region from June 2019 to June 2020 were selected，and the baseline data of patients were investigated and recorded.There were 22 males and 51 females aged 63 to 82 years，with an average age of (71.25±4.31) years.The serum markers of bone metabolism，including blood calcium，blood phosphorus，BALP and bonegla protein (BGP) of patients were detected.Bone volume and bone mineral density were measured by imaging examination.All patients were treated with calcium and/or vitamin D for 24 weeks，the changes of serum markers of bone metabolism，bone volume and bone mineral density were compared before and 24 weeks after treatment.The correlation of bone metabolism with bone volume and bone mineral density was analyzed.The bone volume of patients with different data was compared，and the correlation between BALP and bone volume was mainly analyzed.Results There was no statistical significant difference in the comparison of serum calcium and phosphorus levels before and 24 weeks after treatment (P＞0.05).After 24 weeks of treatment，the serum BALP level was lower than that before treatment，and the serum BGP level，bone volume and bone mineral density were higher than those before treatment.There was a statistical significant difference (P＜0.05)；Pearson correlation analysis showed that blood calcium and serum BALP levels were negatively correlated with bone volume and bone mineral density (r＝－0.294、－0.776，P＜0.05)，blood phosphorus and serum BGP levels were positively correlated with bone volume and bone mineral density (r＝0.322、0.640，P＜0.05).There was no statistical significant difference in the comparison of bone volume between patients with different gender，age，blood calcium and phosphorus (P＞0.05).The bone volume of patients with high serum BALP level was less than that of patients with normal serum BALP level，and the bone volume of patients with low serum BGP level was less than that of patients with normal serum BGP level.There was a statistical significant difference (P＜0.05).By multiple linear regression analysis，the results showed that the abnormal expression of serum BALP and BGP might be related to the bone volume of OP patients，the overexpression of BALP and low expression of BGP might be the influencing factors of bone volume reduction in OP patients (P＜0.05).
Conclusion The bone volume and bone mineral density of elderly OP patients can be improved by treatment，and the poor improvement of bone volume and bone mineral density may be related to the overexpression of BALP.The overexpression of BALP is negatively correlated with bone volume.With the increase of serum BALP，the bone volume is decreased.
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Corresponding Authors:
Peng Yi
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