血清软骨寡聚基质蛋白水平与膝骨关节炎发生发展的关系研究

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Abstract

Objective To analyze the relationship between serum cartilage oligomeric matrix protein (COMP) level and the occurrence and development of knee osteoarthritis (KOA).Methods 255 patients with bilateral KOA admitted to our hospital from April 2012 to March 2019 were selected as the KOA group，and 100 healthy volunteers who came to our hospital for physical examination during the same period were selected as the control group.There were 168 males and 87 females in KOA group.The patients aged from 28 to 85 years old，and the average age was (59.77±11.01) years old.There were 67 males and 33 females in the control group.The patients aged from 20 to 86 years，and the average age was (58.96±12.42) years old.The level of serum COMP was detected by enzyme-linked immunosorbent assay.The Kellgren-Lawrence (K/L) scale，the Western Ontario and McMaster Universities(WOMAC) osteoarthritis index and Lequesne index were used to assess KOA disease severity.Results The serum COMP level in KOA group was significantly higher than that in control group (P＜0.001).According to receiver operating characteristic analysis，the area under the curve of KOA at serum COMP level was 0.789.The probability of smoking history，duration of pain and the expression of typeⅢ procollagen amino terminal peptide (PⅢNP) in patients with serum COMP high-level group were higher than those in low serum COMP level group，and the Timed Up and Go test was lower than those in low serum COMP level group (P＜0.05).Spearman rank correlation analysis showed that serum COMP level was positively correlated with WOMAC，Lequesne index and K/L grade in KOA patients (r＝0.195，0.393，0.481，P＜0.05).Multivariate logistic regression analysis showed that when serum COMP levels were between 2 210.59 to 3 143.87 ng/mL or ＞3 143.87 ng/mL，the risk of moderate and severe progression of K/L grade in patients with KOA increased by 2.091 times and 5.682 times，respectively (P＜0.001).Conclusion Serum COMP level is generally increased in KOA patients，and high serum COMP level is also associated with increased disease severity，which is expected to be a potential biomarker for clinical diagnosis or assessment of disease progression.

Key words： cartilage oligomeric matrix protein knee osteoarthritis Kellgren-Lawrence classification Lequesne index

Corresponding Authors: Li Rong

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	Liu Changhai
	Wang Zhanchao
	Zhang Haojie
	Li Rong

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Liu Changhai,Wang Zhanchao,Zhang Haojie, et al. Study on The Relationship Between Serum Cartilage Oligomeric Matrix Protein and Knee Osteoarthritis[J]. sygkzz, 2023, 29(01): 22-.

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http://www.sygkzz.com/EN/ OR http://www.sygkzz.com/EN/Y2023/V29/I01/22

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