硒与骨质疏松和骨关节炎的相关性研究

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Abstract Objective To analyze the correlation between selenium level in human body and osteoporosis and arthritis.Methods 125 cases of osteoporosi(osteoporosis group) and 117 cases of osteoarthriti(osteoarthritis group) treated in our hospital from January 2017 to January 2020 were included in the study.121 cases were selected in our hospital during the same period.Healthy people undergoing routine physical examination in the hospital served as the control group.There were 21 males and 104 females in the osteoporosis group，with an average age of (66.15±4.78)years and a BMI of (23.11±2.09)kg／m².There were 25 males and 92 females in the osteoarthritis group.The average age was (67.83±4.81)years old，and the BMI was(24.06±2.11)kg／m².The control group included 37 males and 84 females.The average age was(65.39±4.92)years and the BMI was(22.98±2.14)kg／m²；The blood selenium level and bone density of the three groups of subjects were compared，and the correlation between the blood selenium level and osteoporosis and osteoarthritis was analyzed.Results The age and BMI of the control group and the osteoporosis group were significantly lower than those of the osteoarthritis group(P＜0.05)，while the age and BMI of the control group patients were not statistically different from those of the osteoporosis group(P＞0.05).The bone density，selenium，and osteocalcin levels of the osteoporosis group and the osteoarthritis group were significantly lower than those of the control group，while the osteoporosis group was significantly lower than the osteoarthritis group.Type Ⅰ collagen cross-linked C-terminal peptide(C-The levels of telopeptide of type Ⅰ col I，CTX-Ⅰ) and procollagen Ⅰ N-terminal propeptide(PⅠNP) were significantly higher than those of the control group and the osteoarthritis group，and the differences were statistically significant (P＜0.05).Multivariate logistic analysis showed that high CTX-Ⅰ and PⅠNP levels were independent risk factors for osteoporosis and osteoarthritis，while high bone density，selenium and osteocalcin were protective factors to prevent osteoporosis and osteoarthritis.In addition，femalewas independent risk factors for osteoporosis，while advanced age and high BMI were independent risk factors for osteoarthritis (P＜0.05)；Human blood selenium level was positively correlated with bone density (r=0.688，P＜0.001).Conclusion Low blood selenium level is an independent risk factor for osteoporosis and osteoarthritis，and blood selenium level is positively correlated with patients' bone mineral density，which can be used as a relevant intervention target.

Key words： selenium osteoporosis osteoarthritis correlation analysis

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	Li Lei
	Wu Hao
	Wu Liangshao *

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Li Lei,Wu Hao,Wu Liangshao *. Study on the Relationship Between Selenium and Osteoporosis and Osteoarthritis[J]. sygkzz, 2021, 27(8): 708-712.

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http://www.sygkzz.com/EN/ OR http://www.sygkzz.com/EN/Y2021/V27/I8/708

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