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Abstract Objective To research the changes of bone turnover markers in osteopenia patients with fragility fracture and its correlation with occurrence rate of fragility fracture.Methods From January 01 2019 to January 01 2022，we collected 45 osteopenia older women patients with fragility fracture as the observation group and at the same time we set up 71 osteopenia older women patients without fragility fracture as control group in outpatient and hospitalization in Nanjing Hospital of Chinese Medical Affiliated to Nanjing University of Chinese Medicine.There were 45 cases in the observation group，aged 67~78 years，with an average of (75.58±8.44)years.There were 71 cases in the control group，aged 61~91 years，with an average age of (75.34±8.58)years.Age，height，weight，BMI，bone mineral density，bone turnover indicators：OC (osteocalcin)，ALP (alkaline phosphatase)，P1NP(N-terminal peptide of type Ⅰ collagen) and β-CTX(C-terminal peptide of type Ⅰ collagen) and serum Ca-2+concentration were collected and compared.Results There was no significant difference in age，body weight，height and bone mineral density T value between two groups (P＞0.05)，but the average body mass index (BMI) in observation group was higher than that in control group，the difference was statistically significant (P＜0.05).The concentrations of OC，ALP，β-CTX and Ca-2+ in the observation group were higher than those in the control group，the difference was statistically significant (P＜0.05)，while the concentration of P1NP in the observation group was lower than that in the control group，but the difference was not statistically significant (P＞0.05).The incidence of fragility fracture was significantly negatively correlated with body weight，OC，ALP，β-CTX，BMI and Ca-2+.Conclusion Bone conversion markers is required to detect in osteopenia patients by BMD.Patients with significantly increased osteoclasts and osteogenesis markers are at high risk of fragility fracture.The occurrence of fragility fracture is negatively correlated with body weight，OC，ALP，β-CTX，BMI and Ca-2+concentration.
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Corresponding Authors:
Yao Nianwei
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［1］中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊疗指南(2017)［J］.中国骨质疏松杂志，2019，25(3)：281-309.
［2］郑博，蒋涛，黄佳涌，等.我国中老年脆性髋部骨折及桡骨远端骨折骨质疏松诊断标准与WHO诊断标准的比较分析［J］.中国骨质疏松杂志，2018，24(10)：1299-1304.
［3］Macias-Hernandez SI，Degollado-Rodriguez MM，Maldonado-Sanchez H，et al.The yawning gap between osteoporosis diagnosis and treatment after a fragility fracture in Mexico［J］.Arch Osteoporos，2021，16(1)：59.
［4］姚宝红.探究老年骨质疏松性骨折住院患者再次骨折的危险因素［D］.2021.
［5］Zhou J，Liu B，Qin MZ，et al.Fall prevention and anti-osteoporosis in osteopenia patients of 80 years of age and older：A randomized controlled study［J］.Orthopaedic Surgery，2020，12(3)：890-899.
［6］Jain S.Role of bone turnover markers in osteoporosis therapy［J］.Endocrinology and Metabolism Clinics of North America，2021，50(2)：223-237.
［7］Ting BL，Walley KC，Travison TG，et al.Elevated bone turnover markers are associated with distal radius fractures in premenopausal women［J］.J Hand Surg Am，2017，42(2)：71-77.
［8］Rozental TD，Merchan N，Johannesdottir F，et al.Longitudinal changes in serum markers of bone metabolism and bone material strength in premenopausal women with distal radial fracture［J］.J Bone Joint Surg(Am)，2022，104(1)：15-23.
［9］黎卓华，崔敏涛，吴丽川，等.3种骨标志物在绝经后妇女骨质疏松诊断中的研究［J］.国际检验医学杂志，2014，35(7)：914-915.
［10］Slaven SE，Dey D，Yow BG，et al.Longitudinal analysis of circulating markers of bone turnover across multiple decades in osteoporotic women［J］.J Hand Surg Am，2022，47(1)：85；e1-e10.
［11］Roomi AB，Nori W，AlBadry SH.The value of serum adiponectin in osteoporotic women：Does weight have an effect?［J］.J Obes，2021(2021)：5325813.
［12］谢俊杰，张灿，刘夏莹，等，血脂及血清维生素D水平预测老年女性髋部骨质疏松骨折可行性分析［J］.实用骨科杂志，2023，27(3)：210-214，257. |
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