糖尿病合并骨折患者围术期血浆IGF-1、NPY与BAP的变化

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Abstract Objective To study the changes of perioperative plasma levels of insulin-like growth factor-1 (IGF-1)，neuropeptide Y (NPY) and bone alkaline phosphatase (BAP) in diabetic patients with fracture，and to explore their effects on fracture healing in diabetic patients.Methods Seventy patients with lower limb fracture surgery under selective subarachnoid anesthesia from September 2018 to March 2019 were selected.According to whether there was type 2 diabetes，they were divided into the diabetes group and the control group，with thirty-five patients in each group.Diabetes mellitus group included 16 males and 19 females. The mean age was (59.80±8.33) years old.The control group had 18 males and 17 females.The mean age was (54.37±13.07) years old.Two milliliter of elbow-vein blood was extracted pre-operation and 24 hours after surgery，respectively.Plasma was separated and the contents of IGF-1，NPY and BAP in plasma were determined by enzyme linked immunosorbent assay (ELISA).Results The plasma levels of IGF-1，NPY and BAP were significantly higher at 24 hours after surgery than before surgery in the diabetic group and the control group (P＜0.05).The plasma level of IGF-1 in diabetic group was lower than that in control group before and after surgery (P＜0.05).Before surgery，the plasma NPY and BAP levels were significantly higher than that of control group (P＜0.05).After surgery，the increase of NPY in plasma was significantly lower in the diabetic group than that in the control group (P＜0.05).Conclusion IGF-1，NPY and BAP are all involved in the regulation of bone healing repair process.The decrease of IGF-1，the smaller degree of NPY increase and the continuous increase of BAP may be related to delayed bone healing during early stage after fracture surgery in diabetic patients.

Key words： diabetes insulin-like growth factor-1 neuropeptide Y bone alkaline phosphatase fracture healing

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	Li Qi
	Li Lin
	Meng Shanshan
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Li Qi,Li Lin,Meng Shanshan, et al. Changes of Plasma IGF-1，NPY and BAP in Diabetic Patients with Fracture During Perioperative Period[J]. sygkzz, 2021, 27(7): 607-637.

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http://www.sygkzz.com/EN/ OR http://www.sygkzz.com/EN/Y2021/V27/I7/607

［1］刘晓宁，鞠阳，孔德明，等.辛伐他汀对血脂异常绝经糖尿病女性骨密度及上肢骨折愈合的影响［J］.实用骨科杂志，2019，25(3)：220-222.
［2］Jiao H，Xiao E，Graves DT.Diabetes and its effect on bone and fracture healing［J］.Curr Osteoporos Rep，2015，13(5)：327-335.
［3］Kanazawa I，Sugimoto T.Diabetes mellitus-induced bone fragility［J］.Intern Med，2018，57(19)：2773-2785.
［4］Ilhan A，Rasul S，Dimitrov A，et al.Plasma neuropeptide Y levels differ in distinct diabetic conditions［J］.Neuropeptides，2010，44(6)：485-489.
［5］罗怡，斯洁骊，李京晶.2型糖尿病性骨质疏松与血清胰岛素样生长因子-1、骨碱性磷酸酶、1，25羟维生素D3水平的关系［J］.标记免疫分析与临床，2018，25(7)：1001-1004.
［6］Locatelli V，Bianchi VE.Effect of GH/IGF-1 on bone metabolism and osteoporsosis［J］.Int J Endocrinol，2014(2014)：235060.
［7］Blumenfeld I，Srouji S，Lanir Y，et al.Enhancement of bone defect healing in old rats by TGF-beta and IGF-1［J］.Exp Gerontol，2002，37(4)：553-565.
［8］Gu XC，Zhang XB，Hu B，et al.Neuropeptide Y accelerates post-fracture bone healing by promoting osteogenesis of mesenchymal stem cells［J］.Neuropeptides，2016(60)：61-66.
［9］Hashidate H，Kamimura M，Nakagawa H，et al.Early changes in bone specific turnover markers during the healing process after vertebral fracture［J］.Open Orthop J，2011(5)：32-36.
［10］Kanazawa I，Notsu M，Miyake H，et al.Assessment using serum insulin-like growth factor-I and bone mineral density is useful for detecting prevalent vertebral fractures in patients with type 2 diabetes mellitus［J］.Osteoporos Int，2018，29(11)：2527-2535.
［11］Loh K，Zhang L，Brandon A，et al.Insulin controls food intake and energy balance via NPY neurons［J］.Mol Metab，2017，6 (6)：574-584.
［12］Tomlinson DR，Fernyhough P，Diemel LT.Role of neurotrophins in diabetic neuropathy and treatment with nerve growth factors［J］.Diabetes，1997，46 (Suppl 2)：S43-S49.
［13］Kulkarni SV，Meenatchi S，Reeta R，et al.Association of glycemic status with bone turnover markers in type 2 diabetes mellitus［J］.Int J Appl Basic Med Res，2017，7(4)：247-251.
［14］Muljacic A，Poljak-Guberina R，Zivkovic O，et al.Course and rate of post-fracture bone healing in correlation with bone-specific alkaline phosphatase and bone callus formation［J］.Coll Antropol，2013，37(4)：1275-1283.