血脂与老年女性骨质疏松性骨折的相关研究

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Abstract Objective To investigate the relationship between triglyceride (TG)，total cholesterol (TC)，low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) with bone density (BMD) and osteoporotic fractures in elderly women.Methods Retrospective analysis was performed on 110 female osteoporotic patients who underwent outpatient physical examination or were hospitalized from September 2018 to March 2020.The age range ranged from 55~83 years，with an average age of (68.26±6.28)years.According to whether or not osteoporotic fracture occurred，52 cases with an average age of(69.04±6.30)years old(range：56~83 year)were included in fracture group and 58 caseswith an average ago of (67.57±6.24)years old(range：55~80 year) were includedin non-fracture group.Bone mineral density (BMD) and fasting lipid profile were measured in all patients，and general information such as age and body mass index (BMI) were recorded.The relationship between BMD and age，BMI，TG，TC，LDL-C and HDL-C in fracture group was analyzed by Pearson correlation analysis.Correlation coefficient r greater than zero indicated positive correlation，and r less than zero indicated negative correlation.With TC，TG，LDL-C and HDL-C as independent variables，Logistic regression analysis was used to explore the risk factors of osteoporotic fractures in elderly women，P＜0.05 was considered statistically significant.Results In elderly women with osteoporotic fractures，age was negatively correlated with BMD of L_1~4，femoral neck，Ward triangle，greater trochanter，intertrochanteric，and total hip (r<0，P＜0.05)，BMI was positively correlated with BMD in L_1~4and hip regions(r>0，P＜0.05)，TC and TG were negatively correlated with BMD in L_1~4 and hip regions (r<0，P＜0.05)，HDLC had no correlation with BMD in L_1~4 and hip regions (r<0，P＞0.05)，LDL-C was negatively correlated with BMD of Ward triangle，greater trochanter，intertrochanteric and total hip (r<0，P＜0.05).In elderly women，TC was an independent risk factor for osteoporotic fracture，and HDL-C was a protective factor for osteoporotic fracture (P＜0.05).Conclusion In elderly women with osteoporotic fractures，the correlation of TC，TG and LDL-C in blood lipids with BMD at different sites was different，while HDL-C had no correlation with BMD at different sites.In elderly women，TC is a risk factor for osteoporotic fracture，and HDL-C may be a protective factor for osteoporotic fracture.

Key words： osteoporosis osteoporotic fracture blood lipid bone mineral density

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