甲泼尼龙激素对膝关节置换术后早期临床效果的影响

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Abstract Objective To investigation the effect of methyl prednisolone on the early clinical effect after knee arthroplasty with multimode cocktail periarticular injection (MCPI).Methods A prospective randomized controlled trial was conducted in 60 patients from January 2018 to June 2018 with 30 patients in each group.The patients received a combination of methylprednisolone and no methylprednisolone to control postoperative pain.Visual analogue score (VAS) was used to evaluate the pain at rest and activity after operation.The swelling degree of knee joint was observed and the active range of knee motion was measured at different time intervals.Results The results showed that adding methylprednisolone to MCPI could reduce the degree of joint pain and swelling in the early stage (within 24 hours) after operation，and increase the time of active straight leg elevation in advance (P＜0.05)，there was a significant difference between the two groups (P＜0.05).There was no significant difference between the other data (P＞0.05).Steroid hormones also did not increase the risk of postoperative wound infection or tendon rupture.Conclusion Adding methylprednisolone to MCPI can improve the pain relief effect in the early stage (within 24 hours) after total knee replacement，advance the time of raising straight leg，reduce the degree of joint swelling，and have no obvious complications.However，there is no significant effect on the motion of knee joint in the early stage after operation.

Key words： total knee arthroplasty cocktail postoperative analgesia steroid hormone

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