糖尿病大鼠在不同血糖浓度下伤口愈合情况实验研究

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Abstract Objective To study the effect of blood glucose level on the wound healing of diabetic rats.Methods Diabetes mellitus model was built by streptozotocin injection in male rats aged 3~4 months.The diabetes mellitus rats were divided into four groups according to the level of blood gulcose regulated by insulin.The wound model was formed by operation.Afterwards，rats were killed at 0 (the same day of injury)，3，7 and 14 days after injury.The wound healing area was measured，in combination with the observation of the pathological changes of wound tissues.Results When the blood sugar concentration was controlled at 160~190 mg/dL，the wound healing rate was the fastest，followed by at the level lower than 160 mg/dL with no significant difference in macrophages.At higher blood sugar levels，the healing rate of wounds was delayed obviously，and macrophages in surrounding tissues exhibited remarkable decrease.Conclusion It is beneficial to wound healing at low levels of high blood sugar concentration in diabetic rats.

Key words： diabetic rats different blood glucose concentration pathological changes wound healing

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