聚甲基丙烯酸甲酯与磷酸钙和庆大霉素复合型骨水泥的生物力学研究

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Abstract Objective To study the biomechanical properties of bone cement which composed of different proportions of polymethyl methacrylate (PMMA)，β-Tricalcium phosphate (β-TCP) and gentamicin Gentamicin(GM) and to screen out the proportion of ideal composite bone cement.Methods The β-TCP powder was mixed with the corresponding PMMA powder at a total mass ratio of 15%，25%，and 35%，and then the GM powder was separately added to the above three groups at a total mass ratio of 4% to prepare a composite bone cement powder and the bone cement was prepared with 2︰1 solid-liquid ratio as suggested by the manufacture.The injection time of each group of composite bone cement and the strength of the bone cement sample after drying were measured.The samples of each group were immersed in phosphate buffered saline at a ratio of 1︰5，and the corresponding numbered samples were taken at 1 day，3 days，5 days，1 week，2 weeks，3 weeks，and 4 weeks.The Ph value of the soaking solution，the amount of GM released，and the degradation rate and strength of the sample after drying were measured.Results The strength of the composite bone cement slowly decreases after soaking.The in vitro degradation rate and GM release of composite bone cement increased with the increase of soaking time and increased with the increase of β-TCP content.The pH value of the composite bone cement soaking solution decreased with the increase of the soaking time and decreased with the increase of the β-TCP content.Conclusion The β-TCP content of the composite bone cement has an ideal mixing ratio of 35%.The performance of the two groups of bone cement can be combined to the maximum extent，and the desired strength，degradation rate，and GM release amount can be obtained.

Key words： polymethyl methacrylate β-tricalcium phosphate gentamicin bone cement

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