开放性骨折术后创面感染的病原菌及耐药性分析

Abstract
Figure/Table
References (0)
Related Citation (5)

Download: PDF (519 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the distribution and antimicrobial susceptibility of pathogens causing postoperative wound infection in open fracture patients，and provide evidence for rational use of antimicrobial agents in clinical practice.Methods Specimens of patients with postoperative wound infection in the first affiliated hospital of Kunming medical university between June 2012 and June 2016 were collected and underwent microbial culture.Pathogens were identified.Antimicrobial susceptibility tests were performed.Distribution of pathogens and antimicrobial resistance were analyzed.Results Among the 295 patients with postoperative wound infection，male and female accounted for 63.39% and 36.61% respectively.37.97% aged 20～40 years and 35.25% of patients aged 40～60 years.A total of 345 strains were isolated.218(63.19%) of the strains were gram-negative bacteria，mainly Escherichia coli，Pseudomonas aeruginosa and Klebsiella pneumonia.112(32.46%) of them were gram-positive bacteria，mainly Staphylococcus auerus and Staphylococcus epiderrmidis.And 15(4.35%)of them were fungi.The result of antimicrobial susceptibility testing for the major gramnegative pathogens showed that the drug resistance rate to penicillin was the highest(＞96%) and the drug resistance rate to vancomycin was the lowest(0%).The result of antimicrobial susceptibility testing for the major gram-positive pathogens showed that the drug resistance rate to imipenem was the lowest，the drug resistance rate to ampicillin was the lowest.Conclusion The main pathogens causing postoperative wound infection are gram-negative bacteria，different pathogens have different drug resistance.It is necessary for clinicians to use the antimicrobial agents rationally during clinical treatment according to antimicrobial susceptibility testing results and effective measures should also be taken to prevent and control infection.

Key words： open fracture wound infection pathogen drug resistance antimicrobial agents

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Xie Chengcheng
	Chen Nan
	Wu Di

Cite this article:

Xie Chengcheng,Chen Nan,Wu Di. Pathogens and Antimicrobial Resistance of Postoperative Wound Infection in Open Fracture Patients[J]. sygkzz, 2018, 24(8): 682-686.

URL:

http://www.sygkzz.com/EN/ OR http://www.sygkzz.com/EN/Y2018/V24/I8/682

［1］Robin O，Volker G，Thorsten T，et al.Bacterial contamination of open fractures-pathogens，antibiotic resistances and therapeutic regimes in four hospitals of the trauma network Cologne，Germany［J］.Injury，46(Suppl 4)：104-108.
［2］Mohamad J，Michael P.Acute management of open fractures：an evidence-based review［J］.Orthopedics，2015，38(11)：1025-1033.
［3］Lawing CR，Lin FC，Dahners LE，et al.Local injection of aminogly-cosides for prophylaxis against infection in open fractures［J］.J Bone Joint Surg(Am)，2015，97(22)：1844-1851.
［4］Gustilo RB，Anderson JT.Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones：retrospective and prospective analyses［J］.J Bone Joint Surg(Am)，1976，58(4)：453-458.
［5］李筱轶，高伟，冯忠军.开放性骨折手术部位感染的研究［J］.中国感染控制杂志，2010，9(4)：297-300.
［6］Evellard M，Kempf M，Belmonte O，et al.Reservoirs of Acinetobacter baumannii outside the hospital and potential involvement in emerging human community-acquired infection［J］.Int J Infect Dis，2013，17(10)：802-805.
［7］Jedlicka N，Summers NJ.Overview of concepts and treatments in open fractures［J］.Clin Pod Med Surg，2012，29(2)：279-290.
［8］王洽君，何彩虹，章德臻，等.开放性骨折患者内固定术后切口感染因素分析［J］.中华医院感染学杂志，2013，23(24)：6022-6026.
［9］薛彩霞，刘伯让，杨洋.1 654例开放性骨折患者伤口感染病原菌分布及耐药性分析［J］.山东医药，2013，53(45)：69-71.
［10］张静.开放性骨折感染病原菌分布及耐药特征［J］.国际检验医学杂志，2013，34(13)：1676-1678.
［11］金国华，赵胜春，陈欣，等.开放性骨折患者术后伤口感染的细菌学特点及对抗菌药物的耐药性分析［J］.中华医院感染学杂志，2017，27(6)：1321-1324.
［12］Wang J，Zhang H，Wang S.Application of vacuum sealing drainage treatment of internal fixation instrument exposure after early postopearative infection［J］.Minerva Chir，2015，70(1)：17-22.
［13］姚岚，马琳，惠艳.社区获得性耐甲氧西林金黄色葡萄球菌感染的研究现状［J］.中华医院感染学杂志，2011，21(22)：4868-4869.
［14］Laxminarayan R，Duse A，Wattal C，et al.Antibiotic resistancethe need for global solutions［J］.Lancet Infect Dis，2013，13(12)：1057-1098.
［15］孙炳慧.某院骨科住院患者医院感染危险因素回顾性调查［J］.中国感染控制杂志，2014，13(2)：78-80.
［16］任有亮，彭笳宸，李政道，等.四肢创伤性骨折术后细菌感染及耐药的地域性特征分析［J］.中华创伤骨科杂志，2016，18(3)：226-232.
［17］Abbott I，Cerqueira GM，Bhuiyan S，et al.Carbapenem resistance in acinetobacter baumannii：laboratory challenges，mechanistic insights and therapeutic strategies［J］.Expert Rev Anti Infect Ther，2013，11(4)：395-409.
［18］王继美，李挺山，沙晓娟，等.2011—2015年住院患者抗菌药物使用强度与分离病原菌耐药性变化［J］.中国感染控制杂志，2017，16(8)：702-707.
［19］Evans BA，Hamouda A，Amyes SG.The rise of carbapapenemresistant acinetobacter baumannii ［J］.Curr Pharm Des，2013，19(2)：223-238.
［20］乔林，夏志林，刘健，等.多中心创伤后慢性骨髓炎的细菌谱特点及药敏分析［J］.中华创伤骨科杂志，2016，18(9)：769-774.
［21］郝明，彭阿钦，张英泽，等.开放性骨折清创术中与感染后细菌培养的调查与分析［J］.中华创伤骨科杂志，2013，15(7)：588-591.