绝经后女性膝骨关节炎性激素水平及其与年龄和病变程度的关系

Abstract
Figure/Table
References (0)
Related Citation (14)

Download: PDF (1204 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To explore the relationship of serum gonadal hormone levels with age and lesion severity in postmenopausal women with knee osteoarthritis.Methods 215 cases of postmenopausal female patients above 50 years old with knee joint replacement surgery or conservative treatment diagnosed as knee osteoarthritis in Shandong Jining the 1st People's Hospital bone and joint surgery from January 2016 to December 2016 were enrolled.According to age，every 10 years as a group，the patients weredivided into three groups.We measured height，weight，calculate body mass index，WOMAC scale score，X-ray and magnetic resonance imaging of the knee T2-mapping.Fasting blood samples were used to detect FSH，LH，estradiol，fasting blood glucose，triglyceride，and total cholesterol.In accordance with the level of FSH was divided into two groups，high FSH group (＞40 mIU／mL) and low FSH group (＜40 mIU／mL).High FSH group had42 cases at the age of 50～60，45 cases at the age of 61～70，26 cases more than 70 years old.Low FSH group had37 cases of 50～60 years old and 40 casesof 61～70 years oldand 25 cases more than 70 years old.WOMAC score and T-2 valueof thetwo groups wereobserved.Results The height，weight，body mass index，blood triglyceride，cholesterol and blood sugar of the postmenopausal women with KOA did not change significantly with the increase of age，and the WOMAC score and the average T-2 value increased significantly.Serum FSH levels were the highest in the 50～60 year old group，and then decreased significantly with age，and serum LH and E2 gradually decreased.The decrease of LH was significant，and E2 was not significant.Compared with the high FSH group，there was no significant difference in age between the two groups，but the WOMAC score and T-2 value increased significantly.Conclusion Knee osteoarthritis is age-related disease.With the decrease of follicle stimulating hormoneandestrogen，osteoarthritis syptomswillincreases.

Key words： knee osteoarthritis postmenopausal women gonadal hormone follicle-stimulating hormone

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://www.sygkzz.com/EN/ OR http://www.sygkzz.com/EN/Y2018/V24/I2/139

［1］蔡婕.卵泡刺激素受体在脂肪组织和卵巢颗粒细胞的表达及其功能［D］.杭州：浙江大学，2008.
［2］张哲，郑清莲.FSHR、LHR在大鼠肾脏组织的表达及相关研究［J］.中医杂志，2009，50(S1)：240-241.
［3］张哲，郑清莲，刘永惠.去卵巢大鼠肾脏组织表达FSHR、LHR［J］.基础医学与临床，2012，32(10)：1179-1182.
［4］白宏伟，陈蕾孙，绪德，等.大鼠胃促黄体生成素及其受体的免疫组化及原位杂交研究［J］.第四军医大学学报，2008，29(15)：1410-1412.
［5］初晨宇，吕葆真，孙岚，等.卵泡刺激素及其受体在大鼠胰腺的共定位观察［J］.解剖学报，2005，36(3)：303-304.
［6］陈蕾，白宏伟，孙绪德，等.大鼠颌下腺黄体生成素及其受体的定位、核心片段的克隆及序列分析［J］.解剖学报，2007，38(5)：572-576.
［7］Parrott JA，Doraiswamy V，Kim G，et al.Expression and action of both the follicle stimulating hormone receptor and the luteinizing hormone receptor in normal ovarian surface epithetlium and ovarian cancer［J］.Mol Cell Endocrinol，2001，172(1-2)：213-222.
［8］Sun L，Peng Y，Sharrow AC，et al.FSH directly regulates bone mass［J］.Cell，2006，125(2)：247-260.
［9］Devleta B，Adem B，Senada S.Hypergonadotropic amenorrhea and bone density：new approach to an old problem［J］.J Bone Miner Metab，2004，22(4)：360-364.
［10］Altman R，Asch E，Bloch D，et al.Development of criteria for the classification and reporting of osteoarthritis.Classification of osteoarthritis of the knee.Diagnostic and therapeutic criteria committee of the American rheumatism association［J］.Arthritis Rheum，1986，29(8)：1039-1049.
［11］季锦飞，戴进，史冬泉.遗传因素和机械因素与膝骨性关节炎发病年龄的关系［J］.中华医学遗传学杂志，2010，27(6)：672-674.
［12］彭小丁，袁凌清.长沙地区女性促卵泡刺激素水平与骨密度和骨质疏松患病率的关系［J］.中国组织工程研究与临床康复，2009，13(33)：6573-6576.
［13］Raynauld JP.Quantitative magnetic resonance imaging of articular cartilage in knee osteoarthritis［J］.Curr Opin Rheumatol，2003，15(5)：647-650.
［14］Li X，Benjamin MC，Link TM，et al.In vivo T(1rho) and T(2)mapping of articular cartilage in osteoarthritis of the knee using 3T MRI［J］.Osteoarthritis Cartilage，2007，15(7)：789-797.
［15］Devleta B，Adem B，Senada S.Hypergonadotropic amenorrhea and bone density：new approach to an old problem［J］.J Bone Miner Metab，2004，22(4)：360-364.
［16］Hosaka Y，Saito T，Sugita S，et al.Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development［J］.Proc Natl Acad Sci USA，2013，110(5)：1875-1880.
［17］Fujimaki R，Toyama Y，Hozumi N，et al.Involvement of Notch signaling in initiation of prechondrogenic condensation and nodule formation in limb bud micromass cultures［J］.J Bone Miner Metab，2006，24(3)：191-198.
［18］Weng X，Lin P，Liu F，et al.Achyranthes bidentata polysaccharides activate the Wnt／β-catenin signaling pathway to promote chondrocyte proliferation［J］.Int J Mol Med，2014，34(4)：1045-1050.
［19］Li X，Peng J，Wu M，et al.BMP2 promotes chondrocyte proliferation via the Wnt／β-catenin signaling pathway［J］.Mol Med Rep，2011，4(4)：621-626.