新疆地区维、汉、哈族骨肉瘤患者流行病学特征分析

Abstract
Figure/Table
References (0)
Related Citation (14)

Download: PDF (568 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the epidemiological characteristics of osteosarcoma in Xinjiang area and provide reference for clinical work.Methods The clinical data of 290 patients with osteosarcoma from January 2002 to June 2016 were reviewed，and related epidemiological information was collected and analyzed.Results The annual number of osteosarcoma in Xinjiang was rising.There were 290 cases of osteosarcoma patients.Uighur was 56.6％ of the total.Male to female ratio was 1.2︰1.0.The age of them were (24.95±16.59)years.11～20 years old was the peak of mobility.The most common sites was around the knee joint (69.7％)，pathological type of conventional osteosarcoma was the majority，accounting for 87.2％ of the total.The first found symptoms were pain and swelling，accounted for 69.3％.41.7％ of the patients were admitted with immobility.Pathological fractures occurred in 7.9％.Ethnic grouping analysis showed that gender，age distribution between different ethnic groups，tumor location and pathological type showed no significant difference (P＞0.05)，there was significant difference of the positive rate of serum alkaline phosphatase (P＜0.05).Conclusion The clinical value of serum alkaline phosphatase in osteosarcoma is higher than that in Han and other nationalities.

Key words： osteosarcoma epidemiology clinical characteristics Xinjiang area

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://www.sygkzz.com/EN/ OR http://www.sygkzz.com/EN/Y2018/V24/I2/130

［1］Sampo M，Koivikko M，Taskinen M，et al.Incidence，epidemiology and treatment results of osteosarcoma in finland-a nationwide population-based study［J］.Acta Oncol，2011，50(8)：1206-1214.
［2］Buckley JD，Pendergrass TW，Buckley CM，et al.Epidemiology of osteosarcoma and ewing's sarcoma in childhood：a study of 305 cases by the children's cancer group［J］.Cancer，1998，83(7)：1440-1448.
［3］Miller RW.Contrasting epidemiology of childhood osteosarcoma，ewing's tumor，and rhabdomyosarcoma［J］.National Cancer Institute Monograph，1981(56)：9-15.
［4］Mirabello L，Troisi RJ，Savage SA.Osteosarcoma incidence and survival rates from 1973 to 2004：data from the surveillance，epidemiology，and end results program［J］.Cancer，2009，115(7)：1531-1543.
［5］Bielack S，Jürgens H，Jundt G，et al.Osteosarcoma：the COSS experience［J］.Cancer Treat Res，2009(152)：289-308.
［6］Clark JC，Dass CR，Choong PF.A review of clinical and molecular prognostic factors in osteosarcoma［J］.J Cancer Res Clin Oncol，2008，134(3)：281-297.
［7］杨湘越.骨肉瘤实验室诊断研究现状和对策［J］.中华临床医师杂志，2012，6(21)：6841-6842.
［8］Ottaviani G，Jaffe N.The epidemiology of osteosarcoma［J］.Cancer Res Treat，2009(152)：3-13.
［9］张如明，卫晓恩；骨肿瘤分类的演进-2002年WHO骨肿瘤分类介绍［J].中华骨科杂志，2006，26(4)：282-285.
［10］Anninga JK，Gelderblom H，Fiocco M，et al.Chemo therapeutic adjuvant treatment for osteosarcoma：where do we stand?［J］.Euro J Cancer，2011，47(16)：2431-2445.
［11］Solooki S，Vosoughi AR，Masoomi V.Epidemiology of musculoskeletal tumors in shiraz，south of Iran［J］Indian J Med Paediatr Oncol，2011，32(4)：187-191.
［12］吴良平，刘向权，尚阳.新疆人口结构的民族差异及其问题研究——基于六普数据的分析［J］.西北人口，2015，1(36)：105-110.
［13］Lamoureux F，Terichet V，Chipoy C，et al.Recent advances in the management of osteosarcoma and forthcoming therapeutic strategies［J］.Expert Rev Anticancer Ther，2007，7(2)：169-181.
［14］Settakorn J，Rangdaeng S，Arpornchayanon O，et al.Epidemiologic study of 112 osteosarcomas in Chiang Mai University Hospital，Thailand［J］.J Med Assoc Thail，2007，90(7)：1400-1405.
［15］Cho Y，Jung GH，Chung SH，et al.Long-term survivals of stage Ⅱb osteosarcoma：a 20-year experience in a single institution［J］.Clinics in orthopedic surgery，2011，3(1)：48-54.
［16］Bramer JAM，Abudu AA，Tillman RM，et a1.Pre-and postchemotherapy alkaline phosphatase levels as prognostic indicators in adults with localized osteosarcoma［J］.Eur J Cancer，2005，41(18)：2846-2852.
［17］葛艳玲，张正.骨型碱性磷酸酶在骨肿瘤诊断中的价值［J］.中华检验医学杂志，2006，29(2)：136-139.
［18］Liu PPL，Leung KS，Lee SM，et a1.Bone-specific alkaline phosphatase in plasma as tumor marker for osteosarcoma［J］.Ontology，1996，53(4)：275-280.
［19］王京生，屠重棋，段宏等，碱性磷酸酶在骨肿瘤诊断中的价值［J］.四川大学学报(医学版)，2008，39(2)：330-331.
［20］Bielack SS，Kempf-Bielack B，Delling G，et al.Prognostic factors in high-grade osteosarcoma of the extremities or trunk：an analysis of 1 702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols［J］.J Surg Oncol，2002，20(3)：776-790.
［21］Xie L，Guo W，Li Y，et al.Pathologic fracture does not influence local recurrence and survival in high-grade extremity osteosarcoma with adequate surgical margins［J］.J Surg Oncol，2012，106(7)：820-825.
［22］Muchantef K，Pollock AN.Osteosarcoma of the lower extremity presenting as a pathologic fracture［J］.Pediatric emergency care，2012，28(9)：936-937.
［23］Mayerson JL.Limb salvage：an acceptable option in select patients with pathologic fracture in high grade osteosarcoma［J］.J Surg Oncol，2010，102(2)：119.
［24］Kim MS，Lee SY，Lee TR，et al.Prognostic effect of pathologic fracture in localized osteosarcoma：a cohort／case controlled study at a single institute［J］.J Surg Oncol，2009，100(3)：233-239.