PTH基因多态性与骨质疏松性骨折的相关性研究

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Abstract Objective To explore the relationship between the polymorphism of PTH gene rs1459015 and bone mineral density(BMD) of osteoporotic fracture in Han nationality in Beijing.Methods The subjects included 127 osteoporotic fracture(fracture group) and 145 non-osteoporotic fracture(control group).All subjects living in Beijing are Han Chinese without relationship.PTH gene polymorphisms were identified by SNaPshot.BMDs of the lumbar spine (L_2～4) and proximal femur including neck，Ward’s，triangle troch and total hip were measured by dual energy X-ray absorptiometry.Allele frequency and genotype frequency were calculated.The BMD difference of two groups and the relationship of the PTH gene polymorphism with BMD of each location in fracture group were analyzed.Results The A and G allele frequency in two groups were 19.7%，80.3% and 18.6%，81.4%，without statistical significance(P＞0.05).AA、AG、GG genotype frequencies of two populations were 3.9%，31.5%，64.6% and 3.4%，30.3%，66.2%，and this difference was not statistically significant(P＞0.05).The BMDs of each location in fracture group were lower than those in control group，and the differences were statistically significant(P＜0.05)，not including the difference of BMD of neck.The BMDs of GG genotype were higher than those of AA and AG genotype in fracture group (P＞0.05).Compared with AA and GG genotypes in fracture group，AG genotype had higher BMD of hip.Conclusion The PTH gene polymorphism is not associated with BMD of osteoporotic fracture.

Key words： parathyroid hormone gene polymorphism osteoporosis bone mineral density fracture

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