Abstract:Objective To study the biomechanical properties of bone cement which composed of different proportions of polymethyl methacrylate (PMMA),β-Tricalcium phosphate (β-TCP) and gentamicin Gentamicin(GM) and to screen out the proportion of ideal composite bone cement.Methods The β-TCP powder was mixed with the corresponding PMMA powder at a total mass ratio of 15%,25%,and 35%,and then the GM powder was separately added to the above three groups at a total mass ratio of 4% to prepare a composite bone cement powder and the bone cement was prepared with 2︰1 solid-liquid ratio as suggested by the manufacture.The injection time of each group of composite bone cement and the strength of the bone cement sample after drying were measured.The samples of each group were immersed in phosphate buffered saline at a ratio of 1︰5,and the corresponding numbered samples were taken at 1 day,3 days,5 days,1 week,2 weeks,3 weeks,and 4 weeks.The Ph value of the soaking solution,the amount of GM released,and the degradation rate and strength of the sample after drying were measured.Results The strength of the composite bone cement slowly decreases after soaking.The in vitro degradation rate and GM release of composite bone cement increased with the increase of soaking time and increased with the increase of β-TCP content.The pH value of the composite bone cement soaking solution decreased with the increase of the soaking time and decreased with the increase of the β-TCP content.Conclusion The β-TCP content of the composite bone cement has an ideal mixing ratio of 35%.The performance of the two groups of bone cement can be combined to the maximum extent,and the desired strength,degradation rate,and GM release amount can be obtained.
[1]Rachner TD,Khosla S,Hofbauer LC.Osteoporosis:now and the future[J].The Lancet,2011,377(9773):1276-1287.
[2]王岩.骨质疏松性椎体压缩骨折的微创治疗[J].中华创伤骨科杂志,2004,6(9):39-42.
[3]Quan R,Ni Y,Zhang L.Short- and long-term effects of vertebroplastic bone cement on cancellous bone[J].J Mech Behav Biomed Mater,2014,35(3):102-110.
[4]Tsoumakidou G,Too CW,Koch G,et al.CIRSE guidelines on percutaneous vertebral augmentation[J].CardioVascular and Interventional Radiology,2017,40(3):331-342.
[5]Chen C,Shen X,Wang J,et al.Comparing pain reduction following kyphoplasty and vertebroplasty:A meta-analysis of randomized and non-randomized controlled trials[J].Orthopade,2017,46(10):855-863.
[6]Rajasekaran S,Kanna RM,Schnake KJ,et al.Osteoporotic thoracolumbar fractures-how are they different? Classification and treatment algorithm[J].J Orthop Trauma,2017,31(4):49-56.
[7]Hemama M,NI Fatemi,Gana R.Percutaneous vertebroplasty in Moroccan patients with vertebral compression fractures[J].Pan Afr Med J,2017(26):225.
[8]Zhang H,Xu C,Zhang T,et al.Does percutaneous vertebroplasty or balloon kyphoplasty for osteoporotic vertebral compression fractures increase the incidence of new vertebral fractures? A Meta-analysis[J].Pain Physician,2017,20(1):13-28.
[9]Filippiadis DK,Marcia S,Masala S,et al.Percutaneous vertebroplasty and kyphoplasty:Current dtatus,New developments and old controversies[J].Cardio Vascular and Interventional Radiology,2017,40(12):1815-1823.
[10]Hemama M,El Fatemi N,Gana R.Percutaneous vertebroplasty in moroccan patients with vertebral-compression fractures[J].Pan Afr Med J,2017,10(3):225.
[11]Hutton WC,Elmer WA,Boden SD,et al.The effect of hydrostatic pressure on intervertebral disc metabolism[J].Spine (Phila Pa 1976),1999,24(15):1507-1515.
[12]Deramond H,Wright NT,Belkoff SM.Temperature elevation caused by bone cement polymerization during vertebroplasty[J].Bone,1999,25(2 Suppl):17-21.
[13]Jaeblon T.Polymethylmethacrylate:properties and contemporary uses in orthopaedics[J].J Am Acad Orthop Surg,2010,18(5):297-305.
[14]Dall'Oca C,Maluta T,Micheloni GM,et al.The Biocompatibility of bone cements:progress in methodological approach[J].Eur J Histochem,2017,61(2):2673.
[15]Koepp HE,Schorlemmer S,Kessler S,et al.Biocompatibility and osseointegration of β-TCP:Histomorphological and biomechanical studies in a weight-bearing sheep model[J].J Biomed Mater Res B Appl Biomater,2004,70 (2):209-217.
[16]Neut D,Hendriks JG,van Horn JR,et al.Pseudomonas aeruginosabil of information and slime excretion on antibiotic-loaded bone cement[J].Acta Orthopaedica,2009,76(1):109-114.
[17]Winkler H.Bone grafting and one-stage revision of THR biological reconstruction and effective antimicrobial treatment using antibiotic impregnated allograft bone[J].Hip International,2012,22(8):62-68.
[18]Wu T,Hua X,He Z,et al.The bactericidal and biocompatible characteristics of reinforced calcium phosphate cements[J].Biomed Mater,2012,7(4):045003.
[19]Schmolders J,Hischebeth GT,Friedrich MJ,et al.Evidence of MRSE on a gentamicin and vancomycin impregnated polymethyl-methacrylate (PMMA) bone cement spacer after two-stage exchange arthroplasty due to periprosthetic joint infection of the knee[J].BMC Infectious Diseases,2014,14(1):144.
[20]Kolk A,Handschel J,Drescher W.Current trends and future perspectives of bone substitute materials-from spaceholders to innovative biomaterials[J].J Craniomaxillofac Surg,2012,40(8):706-718.
[21]杨俊.磷酸钙与聚甲基丙烯酸甲酯制备复合型骨水泥的生物学研究[D].广州:南方医科大学,2015.
[22]尚希福,汤亭亭,戴尅戎.磷酸三钙骨水泥骨长入的实验[J].中国组织工程研究与临床康复,2007,11(18):3504-3507.