组织工程骨激活低氧诱导因子HIF-1α促进骨修复

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摘要低氧诱导因子-1α(hypoxia inducible factor-1α，HIF-1α)是组织细胞在低氧状态下激活相应基因转录的核心调节因子之一，在骨发育和代谢过程中起到十分关键的作用。现将激活HIF1-α信号通路的方法、作用机制和潜在应用价值加以综述。

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	邓正炜 1
	张亚东 2*
	赵世昌 3

基金资助:国家自然基金(5167020114)

通讯作者: 张亚东

作者简介: 邓正炜(1993－ )，男，研究生在读，上海中医药大学，200120。

引用本文:

邓正炜 1，张亚东 2*，赵世昌 3. 组织工程骨激活低氧诱导因子HIF-1α促进骨修复[J]. 实用骨科杂志, 2018, 24(10): 917-921.

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http://www.sygkzz.com/CN/ 或 http://www.sygkzz.com/CN/Y2018/V24/I10/917

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