临床应用软骨组织工程技术修复关节软骨缺损的进展

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摘要关节软骨缺损在临床中的发病率极高，是导致肢体残障的主要原因，并给社会造成了巨大的经济损失。关节软骨血液供应的贫乏使得其修复显得尤为困难，并长期困扰着广大临床医生。该缺损常表现为顽固性疼痛和进行性关节功能减退，最终可引起退行性骨关节炎。Curl等对美国31 516例膝关节损伤患者行关节镜探查，发现有63％的患者存在不同程度的软骨损伤。据统计，美国每年有30 000～100 000例软骨缺损患者需要手术治疗。在2000年，美国骨关节炎治疗费用达600亿美元，预计到2020年骨关节炎花费将增加到1 000亿美元。近年来，随着再生医学和材料学的迅速发展，软骨细胞、软骨组织以及支架材料运用于软骨缺损的修复均取得了显著的效果，而且其修复组织的结构和生物力学性能近似透明软骨。现就软骨组织工程技术在临床上的推广应用进行综述。

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	尤奇 1
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	段小军 2
	杨柳 2
	刘毅 1*

基金资助:国家自然科学基金资助项目(81071484)
重庆市研究生教育教学项目(jyg20163034)
西南医院临床新技术计划项目(SWH2016BZGFGJJ-02)

通讯作者: 刘毅

作者简介: 尤奇(1989－ )，男，研究生在读，遵义医学院附属医院关节外科，563003。

引用本文:

尤奇 1，2，段小军 2，杨柳 2，刘毅 1*. 临床应用软骨组织工程技术修复关节软骨缺损的进展[J]. 实用骨科杂志, 2018, 24(1): 52-56.

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http://www.sygkzz.com/CN/ 或 http://www.sygkzz.com/CN/Y2018/V24/I1/52

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