Abstract：Objective In recent years，attention to non-invasive shock wave therapy which characteristic of fewer side effects and its application in the treatment has increased，this paper intends to explores the mechanisms of extracorporeal shock wave therapy for bone and joint and muscle pain；the function and transformation of Inflammatory during treatment.Methods Forty male Sprague-Dawley rats were randomly divided into normal control group，model control group，experimental group 1 and experimental group 2，10 rats in each group.By comparing the time of inflammation resolution and swelling extent，serum levels of inflammatory factors，inflammatory cells in tissue sections to study the mechanism of shock wave in anti-inflammatory and analgesia.Results The shock wave therapy could alleviate local inflammation，alleviate inflammatory exudation and infiltration of inflammatory cells，improve symptoms，relieve pain，and do no obvious damage to local tissue.It may be related to the increase of anti-inflammatory analgesic factor and the decrease of Inflammatory factor.Conclusion Extracorporeal shock wave therapy alleviate local inflammation and accelerate the dissipation of inflammation which improve symptoms，reduce pain.The mechanism may be related to promote β-endorphin production，inhibition of PGE2，5-HT and other pain factor release and Nitric oxide is also play an important regulatory role in therapy，but it’s mode of action is not clear.
［1］Kondo H，Naitoh I，Ohara H，et al.Efficacy of pancreatic stenting prior to extracorporeal shock wave lithotripsy for pancreatic stones［J］.Dig Liver Dis，2014，47(2)：178-179.
［2］Nguyen DP，Hnilicka S，Kiss B，et al.Optimization of extracorporeal shock wave lithotripsy delivery rates achieves excellent outcomes for ureteral stones：results of a prospective randomized trial［J］.J Urol，2015，194(2)：418-423.
［3］施国伟，张何.体外冲击波碎石治疗输尿管结石疗效分析［J］.现代泌尿外科杂志，2012，17(1)：64-66.
［4］Park C，Lee S，Yi CW，et al.The effects of extracorporeal shock wave therapy on frozen shoulder patients' pain and functions［J］.J Phys Ther Sci，2015，27(12)：3659-3661.
［5］Lizis P.Analgesic effect of extracorporeal shock wave therapy versus ultrasound therapy in chronic tennis elbow［J］.J Phys Ther Sci，2015，27(8)：2563-2567.
［6］Han H，Lee D，Lee S，et al.The effects of extracorporeal shock wave therapy on pain，disability，and depression of chronic low back pain patients［J］.J Phys Ther Sci，2015，27(8)：397-399.
［7］赵一瑾，樊黄，李吴，等.X线定位与痛点定位体外冲击波治疗腰脊神经后支综合征的临床观察［J］.中国康复医学杂志，2011，26(5)：429-432.
［8］姜长林，曲李，孙纪，等.冲击波治疗颈背肌筋膜综合征47例［J］.中国疼痛医学杂志，2010，16(2)：122-123.
［9］Sukubo NG，Tibalt E，Respizzi S，et al.Effect of shock waves on macrophages：A possible role in tissue regeneration and remodeling［J］.Int J Surg，2015，24(Pt B)：124-130.
［10］Mariotto S，de Prati AC，Cavalieri E，et al.Extracorporeal shock wave therapy in inflammatory diseases：molecular mechanism that triggers anti-inflammatory action［J］.Curr Med Chem，2009，16(19)：2366-2372.
［11］de Girolamo L，Stanco D，Galliera E，et al.Soft-focused extracorporeal shock waves increase the expression of tendon-specific markers and the release of anti-inflammatory cytokines in an adherent culture model of primary human tendon cells［J］.Ultrasound Med Biol，2014，40(6)：1204-1215.
［12］Shi F，Zhou D，Ji Z，et al.Anti-arthritic activity of luteolin in Freund's complete adjuvant-induced arthritis in rats by suppressing P2X4 pathway［J］.Chem Biol Interact，2015(226)：82-87.
［13］Qian B，Li F，Zhao LX，et al.Ligustilide ameliorates inflammatory pain and inhibits TLR4 upregulation in spinal astrocytes following complete freund's adjuvant peripheral injection［J］.Cell Mol Neurobiol，2016，36(4)：143-149.
［14］Alves DP，da Motta PG，Lima PP，et al.Inflammation mobilizes local resources to control hyperalgesia：the role of endogenous opioid peptides［J］.Pharmacology，2012，89(12)：22-28.
［15］Schreiter A，Gore C，Labuz D，et al.Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue［J］.FASEB J，2012，26(12)：5161-5171.
［16］Krukowska J，Wrona J，Sienkiewicz M，et al.A comparative analysis of analgesic efficacy of ultrasound and shock wave therapy in the treatment of patients with inflammation of the attachment of the plantar fascia in the course of calcaneal spurs［J］.Arch Orthop Trauma Surg，2016，136(9)：1289-1296.
［17］Chen YT，Yang CC，Sun CK，et al.Extracorporeal shock wave therapy ameliorates cyclophosphamide-induced rat acute interstitial cystitis though inhibiting inflammation and oxidative stress-in vitro and in vivo experiment studies［J］.Am J Transl Res，2014，6(6)：631-648.
［18］Du Y，Cramer M，Lee CA，et al.Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice：relationship to capillary degeneration and permeability［J］.FASEB J，2015，29(5)：2194-2204.
［19］Hossain E，Sarkar D，Chatterjee M，et al.Effect of methanol extract of Bombax malabaricum leaves on nitric oxide production during inflammation［J］.Acta Pol Pharm，2013，70(2)：255-260.
［20］Lee MY，Sun KH，Chiang CP，et al.Nitric oxide suppresses LPS-induced inflammation in a mouse asthma model by attenuating the interaction of IKK and Hsp90［J］.Exp Biol Med(Mayuood)，2015，240(4)：498-507.
［21］Kawahara K，Hohjoh H，Inazumi T，et al.Prostaglandin E2-induced inflammation：Relevance of prostaglandin E receptors［J］.Biochim Biophys Acta，2015，1851(4)：414-421.
［22］Wu Q，Martin RJ，LaFasto S，et al.A low dose of Mycoplasma pneumoniae infection enhances an established allergic inflammation in mice：the role of the prostaglandin E2 pathway［J］.Clin Exp Allergy，2009，39(11)：1754-1763.
［23］Sugita R，Kubota K，Sugimoto K，et al.A novel selective prostaglandin E2 synthesis inhibitor relieves pyrexia and arthritis in Guinea pigs inflammatory models［J］.J Pharmacol Sci，2016，130(2)：128-135.
晋公网安备 14010702070875号