Abstract：Objective To evaluate the effect of improved closed negative pressure drainage device in the treatment of deep wound infection after posterior internal fixation of lumbar spine.Methods From January 2016 to June 2020，a consecutive series of 42 patients with clinical presentation and diagnosis of early deep infection after posterior internal fixation of lumbar spine were analyzed respectively.The patients were divided into 2 groups according to the different methods，with 22 cases of routine closed drainage were included in the control group，There were 15 males and 7 females，the average age was (58.0±4.6)years；and 20 cases of improved closed negative pressure drainage device were included in the observation group.There were 12 males and 8 females，the average age was (56.0±7.9)years.The debridement time，the wound healing time and the days of hospitalization of 2 groups were compared，erythrocyte sedimentation rate(ESR)，C-reactive protein(CRP) were observed.Results All patients were followed up from 12 to 24 months with an average of (16.4±2.4)months.All the incisions healed completely in the end.Compared with the control group，the observation group had less debridement times and shorter healing time.There was a significant difference between the two groups (P＜0.05).The hospitalization days in the observation group were less than those in the control group (P＜0.05).At 3 days after debridement，the CRP and ESR decreased significantly in all patients，additionally ESR and CRP continued to decrease at 1 month and returned to the normal ranges at 3 months.There were no complications such as recurrence of infection，loosening and fracture of internal fixation at the last follow-up in two groups.Conclusion The improved vacuum-assisted closure technique can significantly reduce the times of debridement，accelerate the wound healing and shorten the length of hospital stay.
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