Abstract：Objective To investigate the effect of low molecular weight heparin (LMWH) on the prevention of lower extremity deep vein thrombosis (DVT) after Oxford-Ⅲ unicompartmental knee arthroplasty.Methods a retrospective case-control study was conducted to analyze 93 patients who underwent unicompartmental knee arthroplasty with Oxford Ⅲ prosthesis from May 2018 to December 2019.According to the inclusion and exclusion criteria，they were divided into QD group and bid group with dosage and frequency of low molecular weight heparin.63 patients were followed up for 1 month.The QD group was injected subcutaneously 4 000 AxaIU/D at 8：00 am.The application started on the first day after surgery.The BID group was used twice a day，and it was applied from the first day after surgery with 3 000 AxaIU subcutaneous injectionat 8：00 am and 16：00 pm.Finally，63 patients were followed up for 1 month after surgery.The data of operation time，anesthesia mode，body mass index and complications were recorded.The preoperative test indexes included platelet，prothrombin time，activated partial thromboplastin time，fibrinogen，D-dimer，total cholesterol and triglyceride.The score of risk assessment table of caprini thrombus was recorded.The early mobilization after operation and the results of lower extremity vein color Doppler ultrasound were recorded.Results 63 patients were followed up for 1 month.There was no deep vein thrombosis of the lower extremity after operation，7 cases had intramuscular vein thrombosis，no wound bleeding and no blood transfusion during hospitalization.One month after discharge，no DVT occurred.There was no statistical difference among the data before，during and after the operation.The difference of hemoglobin concentration was statistically significant.Conclusion Low molecular weight heparin (4 000 AxaIU)can prevent the deep vein thrombosis of the lower extremity after UKA.The frequency of QD can prevent the deep vein thrombosis of the lower extremity.The frequency of BID，3 000 AxaIU/time can increase the recessive blood loss.
赵云超，王鑫 *，房庆鹏，杨毅婕，王朋朋，李晓明，周婷婷. Oxford-Ⅲ膝单髁置换术后低分子肝素使用量疗效分析[J]. 实用骨科杂志, 2020, 26(11): 987-991.
Zhao Yunchao，Wang Xing *，Fang Qingpeng，et al. An Analysis of the Effect of Low Molecular Weight Heparin Use After Unicompartmental Knee Arthroplasty with Oxford Ⅲ. sygkzz, 2020, 26(11): 987-991.
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