锌对脊髓缺血再灌注损伤保护作用的研究进展

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摘要脊髓缺血再灌注损伤(spinal cord ischemiareperfusion injury，SCII)是脊髓缺血缺氧的因素消失，重新恢复血供后，其神经功能不仅没有得到改善，其缺血损伤程度较原水平反而进一步加重，甚至出现脊髓组织神经元不可逆的迟发性死亡的病理状态。血管外科、胸外科和脊柱外科手术因SCII的发生而复杂化，造成一系列并发症，如脊髓功能障碍、术后感觉丧失、运动功能损害(如膀胱和肠道)和不可逆的性功能障碍。这些不良事件给患者及其家属带来了巨大的心理和经济负担。锌是一种人体所必需的微量矿物质元素，在抵抗SCII的多种代谢和信号通路中起着关键作用，在多种新陈代谢和生理功能中也起到了重要作用。此外，锌还是体内300多种酶和许多其他生物因子(包括激素、细胞因子、肽和生物膜)发挥作用所必需的微量元素。由于锌广泛参与蛋白质的组成，对蛋白质发挥其正常功能具有不可或缺的作用，因此锌对于多种生命活动(例如生长发育，免疫应答，基因表达，伤口愈合)也是必不可少的。本文就锌对SCII 的几个保护作用作一综述。

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	刘智明
	尹飞 *

通讯作者: 尹飞

作者简介: 刘智明(1994－ )，男，研究生在读，吉林大学中日联谊医院骨科，130033。

引用本文:

刘智明，尹飞 *. 锌对脊髓缺血再灌注损伤保护作用的研究进展[J]. 实用骨科杂志, 2021, 27(9): 824-828.

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http://www.sygkzz.com/CN/ 或 http://www.sygkzz.com/CN/Y2021/V27/I9/824

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