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Abstract Objective To analyze the related factors of Ewing's sarcoma prognosis，and to construct a nomogram to predict the long-term survival rate of patients.Methods The clinical data of 1 110 patients with primary tumors with Ewing's sarcoma registered in the SEER database from 2004 to 2015 were collected to analyze the risk factors affecting the prognosis of patients.The nomogram map was constructed and verified internally，and the accuracy of the prediction model was evaluated using the consistency index (C-index).Results The cumulative survival rates of 1 110 patients with ES in 3，5，and 10 years were 70.46% (70.43% to 70.49%)，61.70% (61.67% to 61.73%)，and 54.41% (54.37% to 54.45%)，respectively.Multivariate COX regression analysis showed that age，race，T stage，N stage，M stage，and whether surgery were independent risk factors for the prognosis of patients with Ewing sarcoma (P＜0.05).Then we construct a nomogram prediction model based on six independent risk factors.The calibration curves of 3，5，and 10 years survival rates showed a high consistency between the nomogram prediction model and the actual observed survival rate (C-index = 0.717，95% CI = 0.708 to 0.726).Conclusion The predictive effect of the nomogram scoring system for ES patients with 3，5，and 10 years is better，which provides an alternative visual survival prediction chart for the clinic.
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