利塞膦酸钠对骨质疏松性骨折大鼠愈合影响及生物力学评价

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Abstract Objective To evaluate the effect of risedronate on the healing of osteoporotic fracture in rats by relevant biomechanics.Methods Ninety healthy female SD rats aged 6 months were randomly divided into A，B，and C₃ groups：normal control group (group A)，ovariectomized model + femoral shaft fracture model + risedronate sodium.Treatment group (group B) and ovariectomized model + femoral shaft fracture model + saline gavage group (group C).Before the fracture modeling of each group，10 paw withdrawals were randomly selected，and the BMD value of the right femur fracture healing was detected.After the sacrificed rats，the right femoral stem was taken to detect the maximum load at the new epiphysis，the maximum load recovery rate.At the 3rd and 6th week after fracture modeling，rats in each group were tested again.Results In the modeling of fractures of rats in each group，the BMD value group and the intra-group comparison，before the modeling group，the P>0.05，the results were not statistically significant.In the comparison of mean values between groups and groups，the results were statistically significant(P＜0.05).In the comparison between the biomechanical properties of the groups before and after the modeling of osteoporotic fractures in each group，the results were statistically significant(P＜0.05)，except in the maximum load recovery rate.In the comparison between groups B and C，the results were not statistically significant.In the maximum load，the results were not statistically significantin Group C.Conclusion The short-term application of risedronate sodium can promote the healing of osteoporotic fractures.

Key words： osteoporotic fracture bone mineral density biomechanics risedronate sodium

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