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Abstract Objective To investigate the association of TNF-α gene polymorphisms at position -238A/G and -308A/G with spine tuberculosis.Methods We randomly selected 58 cases of spinal tuberculosis patients and 50 normal people as control group from January to December in 2015 of Sixth Affiliated Hospital in Xinjiang Medical University.Gene polymorphisms with the -308A/G and-238A/G of TNF alpha were studied.Results There was significant difference in genotype frequencies of region at position -238GG and GA in TNF-α gene between spinal tuberculosis patients and control group，P＜0.05.There was no significant difference in allele frequencies of region at position-238G and A between two groups，P＞0.05.There was no significant difference in genotype frequencies of region at position-308GG and GA in TNF-α gene between two groups，P＞0.05.There was significant difference in allele frequencies of region at position -308G and A between two groups，P＜0.05.Conclusion TNF-α genes involved the development process of spinal tuberculosis，and gene polymorphism was susceptibility with TB，-308 A allele and -238 GA gene may be involved with the occurrence of spinal tuberculosis.
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［1］赵晓丹，王飞飞，赵鸿飞，等.脊柱结核与化脓性脊柱炎CT鉴别诊断［J］.实用放射学杂志，2015，31(4)：621-622.
［2］Patil T，Garg RK，Jain A，et al.Serum and CSF cytokines and matrix metalloproteinases in spinal tuberculosis［J］.Inflamm Res，2015，64(2)：97-106.
［3］Chen H，Cheng C，Li M，et al.Expression of TNF-α，IFN-γ，TGF-β，and IL-4 in the spinal tuberculous focus and its impact on the disease［J］.Cell Biochem Biophys，2014，70(3)：1759-1764.
［4］Bayley JP，Ottenhoff TH，Verweij CL.Is there a future for TNF promoter polymorphisms［J］.Genes Immum，2012，37(5)：315-329.
［5］Guo C，Zhang H，Gao Q，et al.Monocyte chemoattractant protein-1 in spinal tuberculosis：-362G/C genetic variant and protein levels in Chinese patients［J］.Diagn Microbiol Infect Dis，2014，78(1)：49-52.
［6］Gao Q，Du Q，Zhang H，et al.Monocyte chemotactic protein-1-2518 gene polymorphism and susceptibility to spinal tuberculosis［J］.Arch Med Res，2014，45(2)：183-187.
［7］Allie N，Alexopoulou L，Quesniaux VJ，et al.Protective role of membrane tumour necrosis factor in the hosts resistance to mycobacterial infection［J］.Immunology，2008，125(4)：522-534.
［8］Rivoisy C，Tubach F，Roy C，et al.Paradoxical anti-TNF-associated TB worsening：Frequency and factors associated with IRIS［J］.Joint Bone Spine，2016，83(2)：173-178.
［9］李得春.肿瘤坏死因子仪308和肿瘤坏死因子仅238位点基因多态性与藏族骨关节结核发病关系研究［J］.中国全科医学，2015，18(6)：646-647.
［10］Selvaraj P，Sriram U，Mathan KS，et al.Tumour necrosis factor alpha(-238 and -308)and beta gene polymorphisms in pulmonary tuberculosis haplotype analysis with HLAA，B and DR genes［J］.Tuberculosis，2001，81(5/6)：335-341.
［11］Vejbaesya S，Chierakul N，Luangtrakool P，et al.NRAMP1 and TNF-alpha polymorphisms and susceptibility to tuberculosis in Thais［J］.Respirology，2007，12(2)：202-206.
［12］林春燕，杨玉芳，方菊飞，等.骨关节结核与TNF-α基因多态性的关系［J］.中国脊柱脊髓杂志，2011，21(5)：427-428. |
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