氨甲环酸联合铁剂方案减少全膝关节置换术失血的随机对照研究

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Abstract Objective To investigate the clinical efficacy and safety of tranexamic acid combined with sucrose iron in total knee arthroplasty (TKA).Methods From January 2016 to June 2017，180 patients were enrolled in this study and randomly assigned to tranexamic acid combined iron group (combined group)，tranexamic acid group and iron group.Record replacement at admission，the day before surgery，after surgery，three，five days of hemoglobin concentration，hematocrit.The number of blood loss，postoperative drainage and postoperative blood transfusion were recorded.Besides，the amount of preoperative blood volume，total blood loss were recorded.Results The average age of the patients was 65 years.All preoperative data were not statistically significant (P＞0.05).The levels of preoperative hemoglobin in combination group and iron group were significantly higher than those in group tranexamicacid group (P＜0.05).At the same time，the blood loss and total blood loss were significantly lower in the combined group than in the group (P＜0.05).There were no complications such as infection，deep vein thrombosis，pulmonary embolism during follow-up.Conclusion Tranexamic acid and iron can effectively improve the perioperative hemoglobin concentration，reduce the total blood loss，reduce postoperative blood transfusion.

Key words： tranexamic acid sucrose iron total knee arthroplasty blood loss

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