给氧负压伤口治疗在骨科慢性伤口中的可行性研究

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Abstract Objective To evaluate the feasibility to treat chronic wound in orthopedics with method of vacuum assisted closure (VAC) combined with irrigation of oxygen.Methods 60 patients with traumatic chronic wound in orthopedics were divided into 2 groups (30 cases in each groups).VAC was performed in control group for 10 days，while VAC combined with irrigation of oxygen (2 liters/min)was performed in observation group for 10 days as well.pH value of wound exucation，temperature of wound，PUSH (pressure ulcer scale for healing) scores，granulation tissue coverage rate，skin graft survival，the time to reach the required skin grafting conditions and healing time and cure rate of each group were recorded at 0 d and 10 d.Results After ten days of treatment，in the observation group，pH value of wound bed exudate(7.50±0.26) was lower than that of the control group，(7.22±0.16)(P＜0.01)，The time to reach the required skin grafting conditions(12.65±7.16)was lower than that of the control group(18.28±8.85)(P＜0.01).The temperature of wound bed(34.02±0.41)was higher than that of the control group (33.25 ±0.35)(P＜0.01).The granulation tissue coverage rate (34.30±2.83)% was higher than that of the control group(27.27 ±3.54)%(P＝0.00).The Skin graft survival (93.22±1.91)% was higher than that of the control group (83.21±1.86)%(P＝0.00).There was no statistically significant difference between the PUSH score results of the two groups(P＞0.05).All patients were followed up for 3 months.The cure rate was 86.67%(26/30) in observation group and 53.33%(16/30) in control group.The healing time was (35±15.5)day in observation group and(49±23.4) d in controlling group.There were statistically significant difference between the two groups (P＜0.05 respectively).Conclusion VAC combined with irrigation of oxygen can promote granulation tissue growth and wound healing.The method is feasible and is better than VAC therapy.

Corresponding Authors: Huan Xuelai

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