体外冲击波对肌肉骨骼痛症的抗炎镇痛机制

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Abstract Objective In recent years，attention to non-invasive shock wave therapy which characteristic of fewer side effects and its application in the treatment has increased，this paper intends to explores the mechanisms of extracorporeal shock wave therapy for bone and joint and muscle pain；the function and transformation of Inflammatory during treatment.Methods Forty male Sprague-Dawley rats were randomly divided into normal control group，model control group，experimental group 1 and experimental group 2，10 rats in each group.By comparing the time of inflammation resolution and swelling extent，serum levels of inflammatory factors，inflammatory cells in tissue sections to study the mechanism of shock wave in anti-inflammatory and analgesia.Results The shock wave therapy could alleviate local inflammation，alleviate inflammatory exudation and infiltration of inflammatory cells，improve symptoms，relieve pain，and do no obvious damage to local tissue.It may be related to the increase of anti-inflammatory analgesic factor and the decrease of Inflammatory factor.Conclusion Extracorporeal shock wave therapy alleviate local inflammation and accelerate the dissipation of inflammation which improve symptoms，reduce pain.The mechanism may be related to promote β-endorphin production，inhibition of PGE2，5-HT and other pain factor release and Nitric oxide is also play an important regulatory role in therapy，but it’s mode of action is not clear.

Key words： extracorporeal shock wave inflammation analgesia anti-inflammatory randomized controlled trial

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