急性创伤性骨折后Glu、GSP、EGF及TGF-β1变化分析

Abstract
Figure/Table
References (0)
Related Citation (3)

Download: PDF (472 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective To investigate the variation and clinical significance of blood glucose (Glu)，glycosylated serum protein (GSP)，epidermal growth factor (EGF) and transforming growth factor beta 1 (TGF-β1) levels after acute traumatic fractures.Methods 150 cases of patients with acute traumatic fractures in our orthopaedic department were selected from 2010 to 2015，and were retrospectively analyzed.There were 32 cases with diagnosis of diabetes under hypoglycemic therapy (known group)，21 cases diagnosed diabetes after admission (unknown group)，and 97 cases fracture patients without diabetes (non-diabetes group).At the same time，40 healthy patients were selected as the healthy group.The serum Glu，GSP，EGF，TGF-β1 levels were detected and analyzed before admission and after fracture for 2 weeks.Results The Glu levels of the known group，the unknown group’s and non-diabetes group were significantly higher than that of the healthy group (P＜0.05) during admission.The GSP levels of the unknown group was significantly higher than the known group，the non-diabetes group and the healthy group (P＜0.05); The Glu levels of the four groups had no statistical significance after operation for 2 weeks(P＞0.05)，while the GSP levels of the unknow group was significantly higher than the known group，the non-diabetes group and the healthy group (P＜0.05).The EGF，TGF-β1 levels in non-diabetes group were significantly higher than the known group，the unknown group and the healthy group with statistically difference (P＜0.05).Conclusion The serum Glu level can be the observation index for traumatic stress of post fracture，and the GSP can identify the reason of high Glu levels in patients.The serum EGF，TGF-β1 levels variation may be associated with fracture healing ability of patients.

Key words： acute traumatic fracture blood glucose glycosylated serum protein

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	Guo Qi 1
	Cai Xianhua 2

Cite this article:

Guo Qi 1,Cai Xianhua 2. The Variation Analysis of Glu，GSP，EGF and TGF-β1 after Acute Traumatic Fractures[J]. sygkzz, 2016, 22(11): 992-1001.

URL:

http://www.sygkzz.com/EN/ OR http://www.sygkzz.com/EN/Y2016/V22/I11/992

［1］王涛，王永胜，刘志斌.白细胞介素、转化生长因子在骨质疏松性股骨骨折患者中的诊断意义［J］.中国实验诊断学，2014，12(8)：1328-1330.
［2］余志平，余高瞻，洪江.骨折延迟愈合与血浆TGF-β1浓度的相关性分析［J］.放射免疫学杂志，2013，26(6)：850-851.
［3］陈世彦，张勇.牛痘疫苗致炎兔皮提取物注射液促进创伤性骨折愈合及止痛的临床观察［J］.现代仪器与医疗，2015，21(3)：43-45.
［4］Ashraf MO，Jones HM，Kanvinde R.Acute traumatic fracture dislocation of proximal tibiofibular joint：Case report and literature review［J］.Injury-international Journal of the Care of the Injured，2015，46(7)：1400-1402.
［5］Sclafani MP，Amin NH，Elizabeth D，et al.Rehabilitation following an acute traumatic first rib fracture in a collegiate football player：a case report and literature review.［J］.International Journal of Sports Physical Therapy，2014，9(7)：1021-1029.
［6］李晓楠，刘军权.创伤性骨折患者血糖和糖化血清蛋白检测价值比较［J］.检验医学，2015，7(2)：152-155.
［7］成善泉，陈国邦，刘亿华.椎间盘退变的形态学分型中转化生长因子-β1表达的临床意义［J］.河北医学，2013，19(2)：270-272.
［8］陈玉凤，郭献山，王林栋，等.糖尿病合并非创伤性骨折的发生部位和危险因素［J］.郑州大学学报(医学版)，2015，9(1)：138-141.
［9］徐必生，邓敏，袁华兵，等.开放性胫腓骨骨折感染的危险因素调查［J］.中华实验和临床感染病杂志(电子版)，2015，12(3)：83-85.
［10］王凡，胡阳春，韩锋，等.表皮生长因子对脑损伤患者骨折愈合的影响［J］.重庆医学，2012，41(26)：2738-2739.
［11］陈鑫，魏安伟，李姝，等.尾侧型同源转录因子-2、肝素结合性表皮生长因子样生长因子和骨形态发生蛋白-4在Barrett食管中的表达及相互关系［J］.中华消化杂志，2015，35(5)：323-327.
［12］刘巍，梁志刚，张先锋.转化生长因子-β在骨质疏松骨折愈合过程中表达的实验研究［J］.中国药物与临床，2013，7(12)：1562-1564.