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Abstract Objective To determine the natural course of new vertebral fractures after vertebroplasty，analyze the associated risk factors，and investigate the incidence and correlation between adjacent vertebral fracture (AVF) and remote vertebral fracture (RVF).Methods A retrospective analysis was conducted on the clinical data of 260 patients who underwent percutaneous vertebroplasty augmentation surgery in Ma'anshan People’s Hospital from January 2018 to January 2021.75 patients were male and 185 patients were female，with an age range of 62~81 years and a mean age of (67.34±7.21)years.Patients were divided into fracture group and control groups based on the presence or absence of vertebral fractures during a follow-up period of at least 2 years post surgery.The fracture group was further divided into AVF and RVF groups，based on the relationship between the fractured vertebrae and the operated vertebrae.Survival analysis and regression analysis of various risk factors were employed to examine potential differences in occurrence time and risk factors between AVF and RVF.Results Among the 260 patients included in the study，a total of 55 patients presented with newly developed vertebral fractures.42 patients involved adjacent vertebrae，and the average time of onset was (6.2±2.4)months.Furthermore，there were 13 cases of distant fractures，with an average onset time of (12.3±1.6)months.Both singlefactor and multi factor Cox regression analyses were conducted to identify risk factors for AVF and RVF.The results revealed that CT value，treatment with anti osteoporosis drugs，and sagittal imbalance were significant risk factors for AVF (P＜0.05).Additionally，CT value was identified as a risk factor for RVF (P＜0.05).Conclusion The occurrence of AVF is significantly earlier than that of RVF in patients after percutaneous vertebroplasty.The independent risk factors for AVF include CT values，treatment with anti osteoporotic drugs and sagittal plane imbalance.CT values also serve as a common risk factor for both AVF and RVF.
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Corresponding Authors:
Zhou Tao
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