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Abstract Objective To observe the effect of exercise therapy on bone turnover and inflammatory factor level in postmenopausal osteoporosis (PMOP) on the basis of conventional anti osteoporosis drug therapy and analyze the correlation.Methods 72 postmenopausal osteoporosis patients who met the inclusion criteria were selected and randomly divided into an observation group and a control group.The observation group consisted of 36 cases，ranging in age from 52 to 59 years old，with an average age of (56.03±2.86) years.The control group consisted of 36 cases，ranging in age from 50 to 58 years old，with an average age of (55.36±2.88) years.The control group was treated with conventional anti osteoporosis drugs (calcium and phosphonates)，while the observation group received a combination of aerobic exercise and incremental resistance training on the basis of the control group.Bone mineral density (BMD) of L1~4，left neck of femur BMD，serum N-terminal peptide of type I collagen (S-PINP)，serum C-terminal peptide of type I collagen (S-CTX)，interleukin (IL)-6，tumor necrosis factor (TNF)-α Level were measured before treatment and 3 months after treatment respectively.Results The L1~4 BMD and left neck of femur BMD of the two groups were higher than those before treatment，and the BMD of the observation group was significantly higher than that of the control group (P＜0.05).The biochemical indicators of bone turnover marker (BTM) S-PINP and S-CTX in both groups of patients decreased compared with those before treatment，and the observation group was significantly lower than the control group (P＜0.05).Inflammatory markers IL-6 and TNF-α in two groups of patients decreased compared to those before treatment，and the observation group was significantly lower than the control group (P＜0.05).Conclusion Combined exercise therapy can effectively increase BMD of PMOP patients，reduce bone turnover，inhibit inflammatory factors，and then promote the positive balance of bone remodeling，which is conducive to the prevention and treatment of PMOP.
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Corresponding Authors:
Yin Jun
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