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Abstract Objective To evaluate the efficiency and safety of systemic application of tranexamic acid (TA) for blood salvage during operation of proximal femoral nail anti-rotation(PFNA) for patients sustained inter-trochancteric fracture.Methods We retrospectively enrolled 108 patients operated from Janury 2013 to December 2014 and divided them in to two groups which were then named TA group (56 patients)and control group(52 patients)according to whether TA was administrated or not.We then compared change in hemoglobin，transfusion rates，hemoglobin at 4-5 days after operation and complications between the two groups.Results The total blood loss was less for patients in the TA group than for the control group(541.05±162.18)mL versus (803.10±264.86)mL，respectively.The blood transfusion rate was also less for patients in the TA group than for the control group：12.5% (7/56) versus 30.7%(16/52)，respectively.The rate of deep venous thromembolism of two groups had no significant difference.Conclusion Systemic tranexamic acid administration can efficiently reduce blood loss after PFNA without obvious adverse outcomes.
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