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Abstract Objective To prospectively analyze the efficacy and safety of lateral bone cement cannulation combined with modified parapedicular unilateral percutaneous vertebroplasty for thoracolumbar vertebral compression fractures.Methods Data of 40 cases of osteoporotic vertebral compression fracture (OVCF) in thoracic and lumbar segment (T10~L2) meeting the inclusion criteria of this study were collected from January 2019 to December 2020，and the patients including 3 males and 37 females.The age ranged from 61 to 86 years，with an average of (71.1±7.06) years.The distribution of fractured vertebrae was as follows：1 trivertebrae，3 bivertebrae，and 36 single vertebrae，including 4 T10 vertebrae，4 T11 vertebrae，19 T12 vertebrae，15 L1 vertebrae，and 3 L2 vertebrae.The visual analogue scale (VAS) of pain at each time point was recorded before surgery，1d after surgery and at the last postoperative followup，and statistical analysis was performed to compare the differences between the preoperative and postoperative time points.Results All the operations were performed successfully，and the operation time was 20~65 min，with an average of (31.25±9.31) min.All patients were followed up for 10~24 months，with an average of (17.70±4.10) months.No surgical complications occurred in any of the patients.Low back pain VAS score was (6.42±0.58) points before surgery，(2.40±0.49) points 1 d after surgery，and (1.62±0.48) points at the last follow-up.VAS scores at all postoperative time points were significantly improved compared with those before surgery，and the difference was statistically significant (P＜0.05).Conclusion The treatment of thoracolumbar vertebral compression fracture with lateral bone cement cannulation combined with modified parapedicular unilateral percutaneous vertebroplasty is a safe，effective and minimally invasive surgical method for thoracolumbar vertebral compression fracture in the elderly.
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