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Abstract Objective To observe the clinical application effect of Unicompartmental Knee Arthroplasty(UKA) with mobile bearing and fixed bearing platforms in singlecompartment arthritis of the knee joint.Methods 84 patients with anteromedial knee arthritis admitted from January 2018 to January 2019 were selected and randomly divided into a control group and an observation group，with 42 cases in each group.The control group was treated with Link fixed bearing UKA.and there were 20 males and 22 females；age 52 to 88 years，with an average age of (68.16±5.28).There were 13 left knees and 29 right knees.The body mass index was (23.51±3.82)kg/m2.And the average Knee Flexion Angle (KFA) before surgery was (115.62±5.49)°.In the observation group，23 men and 19 women were treated with Oxford mobile bearing UKA.The age ranged from 48 to 89 years，with an average of (68.37±5.43)years.There were 14 left knees and 28 right knees.The body mass index was (23.54±3.75)kg/m2.And the mean preoperative KFA was (115.58±5.37)°.Knee function，pain，range of motion and the occurrence of complications were observed and recorded.Results The HSS scores and KSS scores of the two groups were higher than the preoperative scores at 24 months after surgery in both groups (P＜0.05).There was no significant difference in HSS score and KSS score between the two groups at 24 months after operation (P＞0.05).The postoperative Visual Analogue Scale/Score (VAS) of the two groups were lower than those of the preoperative group (P＜0.05)，and there was no statistically significant difference between the groups (P＞0.05).The postoperative FTA and sagittal tibial Angle (sTA) were significantly smaller in both groups than before surgery (P＜0.05).The maximum KFA and the maximum knee extension angle were significantly better than those before the operation (P＜0.05).The difference between the groups was statistically significant (P＜0.05).There was no statistically significant difference between the two groups in the incidence of postoperative complications such as infection，prosthesis loosening，liner dislocation，joint bleeding and fibrosis，and arthritis progression (P＞0.05).Conclusion Both the mobile and fixed bearing platform UKA can improve knee joint function，relieve pain，improve joint mobility，and reduce the incidence of adverse reactions in the treatment of unicompartment arthritis in the knee joint.
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