2型糖尿病老年男性患者血清铁蛋白、骨硬化蛋白与骨密度的相关性

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Abstract Objective To analyze the correlation between serum ferritin(SF) as well as serum sclerostin(Sost) levels and bone mineral density(BMD) in elderly male patients with type 2 diabetes mellitus(T2DM).Methods The dual-energy X-ray bone densitometers(Challenger，DMS，France) manufactured in France was adopted to determine the BMD in the second to the fourth lumbar vertebra(L_2～4 ) in anteroposterior position，the left femoral neck，the Ward’s triangle area as well as the greater trochanter region of the 48 cases of elderly male T2DM patients with the age of above 70-year-old；in addition，the SF，Sost and glycosylated hemoglobin(HbA1c) levels were determined；then the same measuring method was utilized to measure the same indicators of the 48 cases of elderly male non-T2DM patients with the age of above 70-year-old(the control group)；and retrospective statistical analysis was conducted to analyze the correlation between the SF as well as Sost levels and the BMD in each part.Results Firstly，the Sost(325.56±123.63)pg/mL and SF(565.72 ±237.63)ng/mL levels in the T2DM group were remarkably higher than those in the control group(204.64±84.76)pg/mL and(355.26±107.62)ng/mL，respectively，with the difference being of highly statistical significance(P＜0.01).Secondly，HbA1c was positively correlated with the Sost and SF levels.Thirdly，the Sost and SF levels in the T2DM group were negatively correlated with the BMD in the femoral neck and the Ward’s triangle area，but they showed no correlation with that in the L_2～4 and the greater trochanter region.Conclusion The results indicated that the Sost and SF levels in elderly male patients with T2DM are notably higher than those in elderly male patients with no T2DM；the Sost and SF levels in the former are markedly negatively correlated with the BMD in the hip，which suggested that poor blood glucose control might induce increased Sost and SF levels in elderly male patients with no T2DM，thus inhibits bone formation and finally the decreases BMD in the hip.

Key words： type 2 diabetes mellitus sclerostin serum ferritin bone mineral density

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