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Abstract Objective To explore the risk factors for increased risk of deep venous thrombosis in patients with traumatic orthopedic fracture during operation.Methods We observed and record the case data of sex，age，smoking history，chronic disease，fracture site，preoperative red blood cell count，preoperative platelet count，preoperative cholesterol，preoperative triglyceride，preoperative high density lipoprotein，preoperative low density lipoprotein，intraoperative anesthesia，operation time，input red blood cell volume，input plasma volume，blood recovery volume，tourniquet use time，tourniquet pressure，surgical posture，implantation type，bleeding volume，the quantity of rehydration，the use of antibiotics and the type of surgical incision in traumatic fractures who entered the anesthesia and operating room of 940th Hospital of PLA from April 2018 to May 2019.The data were analyzed by single factor analysis and those whose P＜0.05 in the single factor analysis would be evaluated by multivariate logistic regression analysis.Results single factor analysis showed that preoperative red blood cell count，fracture site，intraoperative anesthesia，bleeding volume，the quantity of rehydration statistically significant (P＜0.05).Multivariate logistic regression analysis showed that fracture of lower limb (P＝0.044，OR=6.552，95% CI：1.051～40.857)，red blood cell count is on the high side (P＝0.006，OR=14.259，95% CI：2.118～96.018)，intravertebral anesthesia (P＝0.010，OR=7.292，95% CI：1.612～32.989)，general anesthesia (P＝0.006，OR=8.034，95% CI：1.799～35.875) were the main independent risk factor leading to increased risk of DVT.Conclusion In patients with traumatic orthopedic fracture，the red blood cell count is on the high side before operation，intravertebral anesthesia or general anesthesia are the risk factor of increased risk of deep venous thrombosis.
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