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摘要 脊髓损伤(spinal cord injury,SCI)通常发生在瞬时的高能量损伤机制之后,是中枢神经系统的破坏性事件,常伴有运动和感觉功能的永久缺失。流行病学数据表明,全球有超过100万人因SCI致残,并且还在呈上升趋势。中国也有大量的SCI患者,其中北京地区的SCI发病率估计为0.06‰,主要原因为跌倒、交通事故和运动相关所致的伤害。SCI缺乏有效的治疗方法,给家庭和社会带来了沉重的负担;可立即破坏神经组织,并直接损伤血管,导致神经元死亡;损伤区域中心血管破裂引起出血和炎症,进一步导致SCI的加重。已有研究指出,损伤修复中再生的轴突是沿着血管生长的,血管再生的异常会延迟损伤组织的再生。因此,探究SCI后病变微环境中的血管反应、促进损伤后血管生成以求改善神经功能,可能是一个用于SCI治疗方向很有前景的靶点。因此,本文就脊髓损伤后局部血管系统的变化和再生及目前使用血管干预修复SCI的尝试作一综述。
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基金资助:黑龙江省博士后科研启动基金(LBH-Q21053) |
通讯作者:
由长城
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作者简介: 乔文涛(1995- ),男,研究生在读,哈尔滨医科大学附属第二医院骨外科,wentaoqiaoo@163.com |
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