Abstract:Objective To investigate the effect of different lumbar intervertebral morphologies on the occurrence of cage subsidence after transforaminal lumbar interbody fusion (TLIF) via a posterior lateral foraminal approach.Methods The clinical and imaging data of 90 patients with degenerative lumbar spine diseases treated with singlesegment TLIF from January 2019 to August 2021 were retrospectively analyzed.Based on the imaging data,the patients were divided into 43 cases in the subsidence group,including 15 men and 28 women with a mean age of (53.56±8.2) years,and 47 cases in the nonsubsidence group,including 8 men and 39 women with a mean age of (58.26±13.53) years.The patients in the two groups were compared in terms of preoperative,postoperative and final followup imaging parameters (intervertebral space height,local anterior convexity angle,endplate morphological parameters,degree of bone redundancy,etc.).The patients were then divided into two groups.There were 46 cases in the group without bone redundancy,of which 15 were male and 31 were female,with a mean age of (50.43±8.76) years,and there were 44 cases in the group with bone redundancy,of which 8 were male and 36 were female,with a mean age of (61.84±11.18) years.The difference in final subsidence was compared between the two groups.Results All patients completed the surgery successfully and were followed up for 12 to 27 months [(14.5±3.6) months]after surgery.The degree of degeneration of the anterior border of the vertebral body and the morphology of the endplate were higher in the subsidence group than in the nonsubmergence group,and the degree of intervertebral space correction was higher in the subsidence group than in the nonsubmergence group.The degree of bone fragmentation was negatively correlated with the degree of subsidence.The above differences were statistically significant (P<0.05).Conclusion Patients with irregular endplate morphology and over supported intervertebral space have a higher likelihood of fusion subsidence after TLIF.Bone redundancy at the anterior edge of the vertebral body has positive significance in maintaining local segmental stability and avoiding fusion subsidence after TLIF.
[1]Ravindra VM,Senglaub SS,Rattani A,et al.Degenerative lumbar spine disease:estimating global incidence and worldwide volume[J].Global Spine J,2018,8(8):784-794.
[2]Wang Y,Deng M,Griffith JF,et al.Lumbar spondylolisthesis progression and de Novo spondylolisthesis in elderly Chinese men and women:A year-4 follow-up study[J].Spine(Phila Pa 1976),2016,41(13):1096-1103.
[3]He D,Li ZC,Zhang TY,et al.Prevalence of lumbar spondylolisthesis in middle-aged people in Beijing community[J].Orthop Surg,2021,13(1):202-206.
[4]Chen E,Xu J,Yang S,et al.Cage subsidence and fusion rate in extreme lateral interbody fusion with and without fixation[J].World Neurosurg,2019(122):e969-e977.
[5]Kuang L,Wang B,Lu G.Transforaminal lumbar interbody fusion versus miniopen anterior lumbar interbody fusion with oblique self-anchored stand-alone cages for the treatment of lumbar disc herniation:A retrospective study with 2-year follow-up[J].Spine(Phila Pa 1976),2017,42(21):E1259-E1265.
[6]Singhatanadgige W,Sukthuayat A,Tanaviriyachai T,et al.Risk factors for polyetheretherketone cage subsidence following minimally invasive transforaminal lumbar interbody fusion[J].Acta Neurochir(Wien),2021,163(9):2557-2565.
[7]Rao PJ,Phan K,Giang G,et al.Subsidence following anterior lumbar interbody fusion(ALIF):A prospective study[J].J Spine Surg,2017,3(2):168-175.
[8]Guha D,Mushlin HM,Muthiah N,et al.Computed tomography hounsfield units as a predictor of reoperation and graft subsidence after standalone and multilevel lateral lumbar interbody fusion[J].World Neurosurg,2022(161):e417-e426.
[9]Park MK,Kim KT,Bang WS,et al.Risk factors for cage migration and cage retropulsion following transforaminal lumbar interbody fusion[J].Spine J,2019,19(3):437-447.
[10]Chen H,Jiang D,Ou Y,et al.Geometry of thoracolumbar vertebral endplates of the human spine[J].Eur Spine J,2011,20(11):1814-1820.
[11]陈虹.胸腰段椎体终板的形态学测量[D].重庆医科大学,2010.
[12]Pappou IP,Cammisa FJ,Girardi FP.Correlation of end plate shape on MRI and disc degeneration in surgically treated patients with degenerative disc disease and herniated nucleus pulposus[J].Spine J,2007,7(1):32-38.
[13]Chen H,Zhong J,Tan J,et al.Sagittal geometry of the middle and lower cervical endplates[J].Eur Spine J,2013,22(7):1570-1575.
[14]Nathan H.Compression of the sympathetic trunk by osteophytes of the vertebral column in the abdomen:An anatomical study with pathological and clinical considerations[J].Surgery,1968,63(4):609-625.
[15]Imagama S,Ando K,Kobayashi K,et al.Impact of pelvic incidence on lumbar osteophyte formation and disc degeneration in middle-aged and elderly people in a prospective cross-sectional cohort[J].Eur Spine J,2020,29(9):2262-2271.
[16]Ge T,Ao J,Li G,et al.Additional lateral plate fixation has no effect to prevent cage subsidence in oblique lumbar interbody fusion[J].J Orthop Surg Res,2021,16(1):584.
[17]Louie PK,Espinoza OA,Fogg LF,et al.Changes in lumbar endplate area and concavity associated with disc degeneration[J].Spine(Phila Pa 1976),2018,43(19):E1127-E1134.
[18]Xie F,Yang Z,Tu Z,et al.The value of Hounsfield units in predicting cage subsidence after transforaminal lumbar interbody fusion[J].BMC Musculoskelet Disord,2022,23(1):882.
[19]薄冉,杨庆国,段文,等.软骨终板形态与椎间盘退变的相关性[J].中国组织工程研究,2012,16(24):4413-4416.
[20]李光灿,李康华,郑连杰,等.全脊柱终板抗压强度分布规律的生物力学研究[J].医用生物力学,2011,26(6):521-526.
[21]Zhou QS,Chen X,Xu L,et al.Does vertebral end plate morphology affect cage subsidence after transforaminal lumbar interbody fusion?[J].World Neurosurg,2019(130):e694-e701.
[22]马铮,丁文元,申勇,等.Modic改变与椎间盘高度及椎体骨质增生的关系[J].中华外科杂志,2013(7):610-614.
[23]梁仁,卢长巍,吴毅华.腰椎间盘退行性变及损伤的生物力学研究进展[J].临床医药文献电子杂志,2018,5(48):198.
[24]李传玲,赵枫,吕辉照,等.腰椎融合术后椎体硬化和骨赘的变化[J].实用骨科杂志,2016,22(12):1087-1090.
[25]Palepu V,Helgeson MD,Molyneaux-Francis M,et al.The effects of bone microstructure on subsidence risk for ALIF,LLIF,PLIF,and TLIF spine cages[J].J Biomech Eng,2019,141(3):031002.
[26]Wu H,Shan Z,Zhao F,et al.Poor bone quality,multilevel surgery,and narrow and tall Cages are associated with intraoperative endplate injuries and late-onset cage subsidence in lateral lumbar interbody fusion:A systematic review[J].Clin Orthop Relat Res,2022(480):163-188.
[27]Hiyama A,Sakai D,Katoh H,et al.Comparative study of cage subsidence in singlelevel lateral lumbar interbody fusion[J].J Clin Med,2022,11(5):1374.
[28]Kaliya-Perumal AK,Soh T,Tan M,et al.Factors influencing early disc height loss following lateral lumbar interbody fusion[J].Asian Spine J,2020,14(5):601-607.
[29]Yang JJ,Yu CH,Chang BS,et al.Subsidence and nonunion after anterior cervical interbody fusion using a stand-alone polyetheretherketone(PEEK) cage[J].Clin Orthop Surg,2011,3(1):16-23.
[30]濮兴孝,王贤帝,赵龙,等.融合器高度对腰椎椎间融合术后结局影响的研究进展[J].中国修复重建外科杂志,2022,36(11):1440-1444.
[31]O'Neill S,Fidelman JM,Haarup LS,et al.Low prevalence of end plate junction failure in danish patients with lumbar disc herniation[J].Sci Rep,2020,10(1):17652.